Haemodialysis is associated with changes in cutaneous microcirculation in diabetes mellitus
| العنوان: | Haemodialysis is associated with changes in cutaneous microcirculation in diabetes mellitus |
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| المؤلفون: | Stephan Coerper, Stefan Beckert, Alfred Königsrainer, K Sundermann, S Wolf |
| المصدر: | Diabetic Medicine. 26:89-92 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Statistics as Topic, Microcirculation, Endocrinology, Diabetic Neuropathies, Reference Values, Renal Dialysis, Diabetes mellitus, Internal medicine, Post-hoc analysis, Diabetes Mellitus, Internal Medicine, medicine, Humans, Foot Ulcer, Dialysis, Aged, Vasomotor, Foot, business.industry, Area under the curve, Blood flow, Middle Aged, medicine.disease, Diabetic foot, Diabetic Foot, Surgery, Regional Blood Flow, Case-Control Studies, Cardiology, Female, business |
| الوصف: | Aims To examine the cutaneous microcirculation on the dorsum of the foot before, during and after haemodialysis in diabetic and non-diabetic patients. Methods Fourteen age-matched patients (seven diabetic, seven non-diabetic) without active foot ulceration were studied. Cutaneous microcirculation was assessed using a micro-lightguide spectrophotometer to measure venous oxygen saturation and relative blood flow determined at two tissue depths: 2 and 6 mm. Cumulative relative changes of each parameter during haemodialysis were calculated as area under the curve. Differences between and within the groups were calculated by Mann–Whitney U-test and anova following post hoc testing, respectively. Results At baseline, relative blood flow at 6 mm tissue depth was significantly greater in diabetic patients (P = 0.048). Thirty minutes after the end of dialysis, relative blood flow at 2 and 6 mm tissue depth was significantly higher in non-diabetic patients (P = 0.048 and P = 0.001). Mean cumulative relative changes in venous oxygen saturation and relative blood flow at 2 mm as well as 6 mm tissue depth were positive for non-diabetic subjects and negative for diabetic patients. Conclusions Haemodialysis is associated with changes in cutaneous microcirculation, which differ between people with and without diabetes. In those without diabetes, we found an increase in blood flow during haemodialysis, whereas blood flow was reduced in diabetic patients. This may be the result of abnormal vasomotor regulation due to distal neuropathy. |
| تدمد: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2008.02610.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359f5f3a6c72f31be55cc65f474a6b2c https://doi.org/10.1111/j.1464-5491.2008.02610.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....359f5f3a6c72f31be55cc65f474a6b2c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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| DOI: | 10.1111/j.1464-5491.2008.02610.x |