Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
| العنوان: | Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring |
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| المؤلفون: | Bo Wang, Chuanzhen Zhao, Zhaoqing Wang, Kyung-Ae Yang, Xuanbing Cheng, Wenfei Liu, Wenzhuo Yu, Shuyu Lin, Yichao Zhao, Kevin M. Cheung, Haisong Lin, Hannaneh Hojaiji, Paul S. Weiss, Milan N. Stojanović, A. Janet Tomiyama, Anne M. Andrews, Sam Emaminejad |
| المصدر: | Science Advances Science advances, vol 8, iss 1 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | endocrine system, Detection, screening and diagnosis, Multidisciplinary, Applied Sciences and Engineering, Clinical Research, Materials Science, SciAdv r-articles, Physical and Materials Sciences, 4.1 Discovery and preclinical testing of markers and technologies, Research Article |
| الوصف: | Description A smartwatch was developed for noninvasive stress biomarker data acquisition that provides real-time feedback to the wearer. Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing. |
| وصف الملف: | application/pdf |
| تدمد: | 2375-2548 |
| DOI: | 10.1126/sciadv.abk0967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3586607d1f04061d7a3c098337ecaae7 https://doi.org/10.1126/sciadv.abk0967 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3586607d1f04061d7a3c098337ecaae7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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| DOI: | 10.1126/sciadv.abk0967 |