Laccase Properties, Physiological Functions, and Evolution
| العنوان: | Laccase Properties, Physiological Functions, and Evolution |
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| المؤلفون: | Andrzej Paszczynski, Grzegorz Janusz, Jolanta Polak, Anna Pawlik, Urszula Świderska-Burek, Justyna Sulej, Anna Jarosz-Wilkołazka |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 3, p 966 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Substrate Specificities, 030106 microbiology, lignin, Review, Multicopper oxidase, Catalysis, Substrate Specificity, Inorganic Chemistry, lcsh:Chemistry, Evolution, Molecular, 03 medical and health sciences, chemistry.chemical_compound, Protein Domains, evolution, Lignin, Humans, Physical and Theoretical Chemistry, polyphenol oxidase, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Phylogeny, Laccase, chemistry.chemical_classification, function, Bacteria, multicopper oxidase, Organic Chemistry, Fungi, SUPERFAMILY, General Medicine, Computer Science Applications, melanin, 030104 developmental biology, Enzyme, chemistry, Biochemistry, lcsh:Biology (General), lcsh:QD1-999, Substrate specificity, Function (biology) |
| الوصف: | Discovered in 1883, laccase is one of the first enzymes ever described. Now, after almost 140 years of research, it seems that this copper-containing protein with a number of unique catalytic properties is widely distributed across all kingdoms of life. Laccase belongs to the superfamily of multicopper oxidases (MCOs)—a group of enzymes comprising many proteins with different substrate specificities and diverse biological functions. The presence of cupredoxin-like domains allows all MCOs to reduce oxygen to water without producing harmful byproducts. This review describes structural characteristics and plausible evolution of laccase in different taxonomic groups. The remarkable catalytic abilities and broad substrate specificity of laccases are described in relation to other copper-containing MCOs. Through an exhaustive analysis of laccase roles in different taxa, we find that this enzyme evolved to serve an important, common, and protective function in living systems. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d50f82889b7a638b9bd06675713976 http://europepmc.org/articles/PMC7036934 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34d50f82889b7a638b9bd06675713976 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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