Serum Cystatin C Measurement in Lupus Nephritis Patients: Its Correlation with Clinical and Histopathological Findings
| العنوان: | Serum Cystatin C Measurement in Lupus Nephritis Patients: Its Correlation with Clinical and Histopathological Findings |
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| المؤلفون: | Alparslan Ersoy, İ̇brahim Akdağ |
| المصدر: | Volume: 2, Issue: 2 35-42 Turkish Journal of Internal Medicine |
| بيانات النشر: | Nizameddin KOCA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, General and Internal Medicine, Serum cystatin C measurement, Lupus nephritis, Renal function, urologic and male genital diseases, Gastroenterology, chemistry.chemical_compound, Internal medicine, medicine, skin and connective tissue diseases, Genel ve Dahili Tıp, reproductive and urinary physiology, General Environmental Science, Creatinine, Proteinuria, medicine.diagnostic_test, biology, business.industry, Creatinine clearance,disease activity index,histopathological findings,serum creatinine,serum cystatin C,systemic lupus erythematosus, medicine.disease, female genital diseases and pregnancy complications, chemistry, Cystatin C, biology.protein, General Earth and Planetary Sciences, Renal biopsy, Cystatin, medicine.symptom, business |
| الوصف: | Introduction To investigate the relationship between serum cystatin C levels and disease activity, renal function test, and histopathological findings in patients with lupus nephritis that did not receive any previous treatment. Methods. 20 patients with lupus nephritis and 20 healthy subjects were included in the study. Before initiation of spesific treatment, clinical and laboratory findings including serum creatinine, cystatin C, daily proteinuria and Cockcroft and Gault (C-G) and Modification of Diet in Renal Disease (MDRD) study equation in adults creatinine clearances (CrCl), as well as histopathological activity and chronicity indices and systemic lupus erythematosus disease activity index (SLEDAI) were evaluated. Results.Serum creatinine, cystatin C, C-G and MDRD CrCls in the patients with lupus nephritis and controls were comparable. Both serum creatinine and cystatin C levels positively correlated with activity index and SLEDAI. There was a negative correlation between C-G CrCl with activity index and MDRD CrCl with activity index and SLEDAI. Conclusions.Our findings suggest that in lupus nephritis measuring the cystatin C level before renal biopsy is performed can not provide a more beneficial predictor than creatinine. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2687-4245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34485da20ab47cf4137a5afa3d744656 https://dergipark.org.tr/tr/pub/tjim/issue/54039/710052 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34485da20ab47cf4137a5afa3d744656 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26874245 |
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