Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin
| العنوان: | Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin |
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| المؤلفون: | Lori A. Smith, Ulla C. Kopp, Tomas Hökfelt, Olaf Grisk, Nicole Mähler, Michael Z. Cicha, Antje Steinbach, Torsten Schlüter |
| المصدر: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 297:R337-R351 |
| بيانات النشر: | American Physiological Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endothelin A Receptor Antagonists, Physiology, Efferent, Myocytes, Smooth Muscle, Gene Expression, Neuropeptide, Blood Pressure, Substance P, Kidney, Efferent Pathways, Models, Biological, Peptides, Cyclic, Dinoprostone, Rats, Sprague-Dawley, Norepinephrine, chemistry.chemical_compound, Piperidines, Ganglia, Spinal, Physical Stimulation, Physiology (medical), Internal medicine, Reflex, medicine, Animals, Kidney Pelvis, Antihypertensive Agents, Afferent Pathways, Endothelin-1, Sodium, Dietary, Articles, Receptor, Endothelin A, Receptor, Endothelin B, Endothelin B Receptor Antagonists, Rats, Endocrinology, medicine.anatomical_structure, chemistry, Catecholamine, Neuroglia, Endothelin receptor, Oligopeptides, medicine.drug |
| الوصف: | Increasing efferent renal sympathetic nerve activity (ERSNA) increases afferent renal nerve activity (ARNA), which in turn decreases ERSNA via activation of the renorenal reflexes in the overall goal of maintaining low ERSNA. We now examined whether the ERSNA-induced increases in ARNA are modulated by dietary sodium and the role of endothelin (ET). The ARNA response to reflex increases in ERSNA was enhanced in high (HNa)- vs. low-sodium (LNa) diet rats, 7,560 ± 1,470 vs. 900 ± 390%·s. The norepinephrine (NE) concentration required to increase PGE2and substance P release from isolated renal pelvises was 10 pM in HNa and 6,250 pM in LNa diet rats. In HNa diet pelvises 10 pM NE increased PGE2release from 67 ± 6 to 150 ± 13 pg/min and substance P release from 6.7 ± 0.8 to 12.3 ± 1.8 pg/min. In LNa diet pelvises 6,250 pM NE increased PGE2release from 64 ± 5 to 129 ± 22 pg/min and substance P release from 4.5 ± 0.4 to 6.6 ± 0.7 pg/min. In the renal pelvic wall, ETB-R are present on unmyelinated Schwann cells close to the afferent nerves and ETA-R on smooth muscle cells. ETA-receptor (R) protein expression in the renal pelvic wall is increased in LNa diet. In HNa diet, renal pelvic administration of the ETB-R antagonist BQ788 reduced ERSNA-induced increases in ARNA and NE-induced release of PGE2and substance P. In LNa diet, the ETA-R antagonist BQ123 enhanced ERSNA-induced increases in ARNA and NE-induced release of substance P without altering PGE2release. In conclusion, activation of ETB-R and ETA-R contributes to the enhanced and suppressed interaction between ERSNA and ARNA in conditions of HNa and LNa diet, respectively, suggesting a role for ET in the renal control of ERSNA that is dependent on dietary sodium. |
| تدمد: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.91029.2008 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c3a7747e85e886b4459c468ca8ef9 https://doi.org/10.1152/ajpregu.91029.2008 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....333c3a7747e85e886b4459c468ca8ef9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221490 03636119 |
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| DOI: | 10.1152/ajpregu.91029.2008 |