Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion
| العنوان: | Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion |
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| المؤلفون: | Anna Wendt, Thomas Reinbothe, Jones K. Ofori, Inês G. Mollet, Karin G. Stenkula, Jenny Vikman, Lena Eliasson, Helena Anna Malm, Jonathan L.S. Esguerra, Vishal A. Salunkhe |
| المصدر: | EBioMedicine, Vol 10, Iss C, Pp 185-194 (2016) EBioMedicine |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Medicin och hälsovetenskap, Glucose uptake, medicine.medical_treatment, lcsh:Medicine, 030204 cardiovascular system & hematology, Glucose homeostasis, Medical and Health Sciences, Mice, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Adipocytes, Medicine, Homeostasis, Insulin, Ca2+ measurements, Rosuvastatin Calcium, lcsh:R5-920, Insulin secretion, Ca(2+) measurements, General Medicine, Beta cell, Muscle, Female, lcsh:Medicine (General), medicine.drug, Research Paper, Islet, medicine.medical_specialty, Adipose tissue, 030209 endocrinology & metabolism, Diet, High-Fat, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Insulin resistance, Diabetes mellitus, Internal medicine, OGTT, Animals, Rosuvastatin, Calcium Signaling, business.industry, lcsh:R, nutritional and metabolic diseases, Statin, medicine.disease, Diet, Ca2 + measurements, High-Fat, Endocrinology, Glucose, Calcium, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Insulin Resistance, business, Transmission electron microscopy |
| الوصف: | Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes. The cellular mechanisms behind the development of diabetes by statins are elusive. Here we have treated mice on normal diet (ND) and high fat diet (HFD) with rosuvastatin. Under ND rosuvastatin lowered blood glucose through improved insulin sensitivity and increased glucose uptake in adipose tissue. In vitro rosuvastatin reduced insulin secretion and insulin content in islets. In the beta cell Ca2 + signaling was impaired and the density of granules at the plasma membrane was increased by rosuvastatin treatment. HFD mice developed insulin resistance and increased insulin secretion prior to administration of rosuvastatin. Treatment with rosuvastatin decreased the compensatory insulin secretion and increased glucose uptake. In conclusion, our data shows dual effects on glucose homeostasis by rosuvastatin where insulin sensitivity is improved, but beta cell function is impaired. Highlights • Rosuvastatin lowered blood glucose in vivo most likely due to improved glucose uptake. • Rosuvastatin reduced insulin content and impaired Ca2 + signaling in beta cells leading to reduced insulin secretion. • Dual effects of rosuvastatin in HFD mice though decreased compensatory insulin secretion and increased glucose uptake. Statins are a group of drugs used to lower blood cholesterol in individuals with a risk of developing cardiovascular disease. It has been shown in several studies that statins increase the risk of developing type 2 diabetes. This increased risk has not yet been explained. We have investigated the effect of rosuvastatin on blood glucose regulation in mice. We found that rosuvastatin has a beneficial effect on glucose uptake in muscles which results in lowered blood glucose. However, in the insulin producing beta cells rosuvastatin altered normal cell function something that might increase the risk of developing type 2 diabetes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2352-3964 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a005eafcd177cf5b02d055efc09a2e http://www.sciencedirect.com/science/article/pii/S2352396416303127 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32a005eafcd177cf5b02d055efc09a2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523964 |
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