Distribution and Function of Platelet-derived Growth Factor Receptor Alpha-positive Cells and Purinergic Neurotransmission in the Human Colon: Is It Different Between the Right and Left Colon?
| العنوان: | Distribution and Function of Platelet-derived Growth Factor Receptor Alpha-positive Cells and Purinergic Neurotransmission in the Human Colon: Is It Different Between the Right and Left Colon? |
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| المؤلفون: | Kil-Yong, Lee, Tae Sik, Sung, Byoung H, Koh, Seung-Bum, Ryoo, Jung Nyeo, Chun, Shin-Hye, Kim, Kyu Joo, Park, Insuk, So |
| المصدر: | Journal of Neurogastroenterology and Motility. 28:678-692 |
| بيانات النشر: | The Korean Society of Neurogastroenterology and Motility, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Gastroenterology, Neurology (clinical) |
| الوصف: | Platelet-derived growth factor receptor alpha-positive (PDGFRαHuman colonic segments were prepared with mucosa and submucosa intact, and the circular muscle tension and longitudinal muscle tension were recorded. Purinergic neurotransmitters were administered after recording the regular contractions. Immunohistochemistry was performed on the circular muscle layers. Intracellular recording was performed on the colonic muscular layer.Adenosine triphosphate (ATP) treatment significantly decreased the frequency and area under the curve (AUC) of the segmental contraction in right and left colons. Beta-nicotinamide adenine dinucleotide (β-NAD) decreased the frequency in the right colon and the amplitude, frequency and AUC in the left colon. Apamin significantly increased frequency and AUC in the left colon, and after apamin pretreatment, ATP and β-NAD did not change segmental contractility. Through intracellular recordings, a resting membrane potential decrease occurred after ATP administration; however, the degree of decrease between the right and left colon was not different. PDGFRαPurines reduce right and left colon contractility similarly, and purinergic inhibitory neurotransmission can be regulated by PDGFRα |
| تدمد: | 2093-0887 2093-0879 |
| DOI: | 10.5056/jnm21117 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32431f28659adfb59c1214a922aa7170 https://doi.org/10.5056/jnm21117 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32431f28659adfb59c1214a922aa7170 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20930887 20930879 |
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| DOI: | 10.5056/jnm21117 |