Development of a passive liquid valve (PLV) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform
| العنوان: | Development of a passive liquid valve (PLV) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform |
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| المؤلفون: | Tzer Hwai Gilbert Thio, Marc J. Madou, Norulain Bahari, Rohana Yusof, Fatimah Ibrahim, Hussin A. Rothan, Wisam Al-Faqheri, Hamzah Arof |
| المصدر: | Al-Faqheri, Wisam; Ibrahim, Fatimah; Thio, Tzer Hwai Gilbert; Bahari, Norulain; Arof, Hamzah; Rothan, Hussin A; et al.(2015). Development of a passive liquid valve (PLV) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform.. Sensors (Basel, Switzerland), 15(3), 4658-4676. doi: 10.3390/s150304658. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8cs8j41h Sensors Volume 15 Issue 3 Pages 4658-4676 Sensors, Vol 15, Iss 3, Pp 4658-4676 (2015) Sensors (Basel, Switzerland) |
| بيانات النشر: | eScholarship, University of California, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Materials science, Capillary action, Airflow, Microfluidics, Mechanical engineering, Centrifugation, lcsh:Chemical technology, pressure equilibrium, Biochemistry, Article, Passive control, Pressure equilibrium, Analytical Chemistry, centrifugal platform, Pressure, lcsh:TP1-1185, Metering mode, Liquid density, Electrical and Electronic Engineering, Instrumentation, Mechanical Phenomena, microfluidic CD, Compact Disks, S-PLV, passive liquid valve, D-PLV, Microfluidic Analytical Techniques, Models, Theoretical, Atomic and Molecular Physics, and Optics, Biological Assay, Liquid height |
| الوصف: | In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/s150304658. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32185260c78d2f6d02e4a71891029e0b http://www.escholarship.org/uc/item/8cs8j41h |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....32185260c78d2f6d02e4a71891029e0b |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.3390/s150304658. |
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