A Sex Perspective in Neurodegenerative Diseases: microRNAs as Possible Peripheral Biomarkers
| العنوان: | A Sex Perspective in Neurodegenerative Diseases: microRNAs as Possible Peripheral Biomarkers |
|---|---|
| المؤلفون: | Elena Ortona, Giada Pontecorvi, Paola Piscopo, Alessio Crestini, Alessandra Carè, Valeria Manzini, Maria Bellenghi, Annamaria Confaloni, Massimo Corbo |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4423, p 4423 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | sex differences, amyotrophic lateral sclerosis, Parkinson's disease, QH301-705.5, Disease, Review, Bioinformatics, Catalysis, Inorganic Chemistry, Sex Factors, microRNA, Medicine, Humans, neurodegenerative diseases, Physical and Theoretical Chemistry, Amyotrophic lateral sclerosis, Biology (General), Molecular Biology, QD1-999, Spectroscopy, business.industry, Incidence (epidemiology), Organic Chemistry, Perspective (graphical), biomarkers, General Medicine, medicine.disease, Sex specific, Computer Science Applications, Peripheral, microRNAs, Chemistry, Parkinson’s disease, business, Alzheimer’s disease |
| الوصف: | Sex is a significant variable in the prevalence and incidence of neurological disorders. Sex differences exist in neurodegenerative disorders (NDs), where sex dimorphisms play important roles in the development and progression of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. In the last few years, some sex specific biomarkers for the identification of NDs have been described and recent studies have suggested that microRNA (miRNA) could be included among these, as influenced by the hormonal and genetic background. Failing to consider the possible differences between males and females in miRNA evaluation could introduce a sex bias in studies by not considering some of these sex-related biomarkers. In this review, we recapitulate what is known about the sex-specific differences in peripheral miRNA levels in neurodegenerative diseases. Several studies have reported sex-linked disparities, and from the literature analysis miR-206 particularly has been shown to have a sex-specific involvement. Hopefully, in the near future, patient stratification will provide important additional clues in diagnosis, prognosis, and tailoring of the best therapeutic approaches for each patient. Sex-specific biomarkers, such as miRNAs, could represent a useful tool for characterizing subgroups of patients. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f68011f0ce8e551bc3d500b04bd85d https://www.mdpi.com/1422-0067/22/9/4423 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....31f68011f0ce8e551bc3d500b04bd85d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
|---|