The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa
| العنوان: | The influence of the host microbiome on 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa |
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| المؤلفون: | Sayantan Roy Choudhury, Sara R. Bodnar, Sudhan Pachhain, Jon E. Sprague, Vipaporn Phuntumart, Ray A. Larsen, Emily A. Ridge |
| المصدر: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Hyperthermia, Male, Fever, N-Methyl-3,4-methylenedioxyamphetamine, lcsh:Medicine, Pharmacology, Gut flora, Article, Iopanoic acid, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Brown adipose tissue, mental disorders, medicine, Animals, Uncoupling Protein 3, Microbiome, lcsh:Science, Proteus mirabilis, Uncoupling Protein 1, Multidisciplinary, biology, Chemistry, Microbiota, lcsh:R, MDMA, Hyperthermia, Induced, biology.organism_classification, medicine.disease, G protein-coupled bile acid receptor, Thermogenin, Rats, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, 030217 neurology & neurosurgery, psychological phenomena and processes, medicine.drug |
| الوصف: | Hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) can be life-threatening. Here, we investigate the role of the gut microbiome and TGR5 bile acid receptors in MDMA-mediated hyperthermia. Fourteen days prior to treatment with MDMA, male Sprague-Dawley rats were provided water or water treated with antibiotics. Animals that had received antibiotics displayed a reduction in gut bacteria and an attenuated hyperthermic response to MDMA. MDMA treated animals showed increased uncoupling protein 1 (UCP1) and TGR5 expression levels in brown adipose tissue and skeletal muscle while increased expression of UCP3 was observed only in skeletal muscle. Antibiotics prior to MDMA administration significantly blunted these increases in gene expression. Furthermore, inhibition of the TGR5 receptor with triamterene or of deiodinase II downstream of the TGR5 receptor with iopanoic acid also resulted in the attenuation of MDMA-induced hyperthermia. MDMA-treatment enriched the relative proportion of a Proteus mirabilis strain in the ceca of animals not pre-treated with antibiotics. These findings suggest a contributing role for the gut microbiota in MDMA-mediated hyperthermia and that MDMA treatment can trigger a rapid remodeling of the composition of the gut microbiome. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f041e5e85ed3a3e22ca94bf73f92d9 https://pubmed.ncbi.nlm.nih.gov/30867489 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....31f041e5e85ed3a3e22ca94bf73f92d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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