Mortality among uranium miners in North America and Europe: the Pooled Uranium Miners Analysis (PUMA)
| العنوان: | Mortality among uranium miners in North America and Europe: the Pooled Uranium Miners Analysis (PUMA) |
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| المؤلفون: | Michaela Kreuzer, Deffner, N. DeBono, Dominique Laurier, Mary K. Schubauer-Berigan, Charles L. Wiggins, Paul A. Demers, David B. Richardson, Kaitlin Kelly-Reif, Ladislav Tomasek, Nora Fenske, Lydia B. Zablotska, Jonathan M. Samet, M.T. Do, Estelle Rage |
| المساهمون: | Department of epidemiology, School of Public Health, University of North Carolina, PSE-SANTE/SESANE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Occupational Cancer Research Centre, Department of Radiation Protection and Health, Federal Office for Radiation Protection (BfS), DEPARTMENT OF RADIATION PROTECTION AND HEALTH, Federal Office for Radiation Protection, (BfS), Colorado School of Public Health, The University of New Mexico [Albuquerque], International Agency for Research on Cancer (IARC), National Institute for Occupational Safety and Health (NIOSH), National Radiation Protection Institute (NRPI/SURO), Department of Epidemiology and Biostatistics, University of California, PSE-SANTE/SESANE |
| المصدر: | International journal of epidemiology, vol 50, iss 2 International Journal of Epidemiology International Journal of Epidemiology, Oxford University Press (OUP), 2021, 50 (2), pp.633-643. ⟨10.1093/ije/dyaa195⟩ |
| بيانات النشر: | eScholarship, University of California, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Canada, Lung Neoplasms, uranium miners, Epidemiology, [SDV]Life Sciences [q-bio], Pulmonary disease, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Occupational Exposure, Germany, medicine, otorhinolaryngologic diseases, Humans, Lung cancer, Cause of death, Excess mortality, business.industry, Mortality rate, Statistics, technology, industry, and agriculture, General Medicine, mortality study, medicine.disease, Calendar period, Confidence interval, respiratory tract diseases, Occupational Diseases, Europe, Radon, 030220 oncology & carcinogenesis, 8. Economic growth, North America, Public Health and Health Services, Uranium, France, business, Demography, Cohort study |
| الوصف: | Background The Pooled Uranium Miners Analysis (PUMA) study draws together information from cohorts of uranium miners from Canada, the Czech Republic, France, Germany and the USA. Methods Vital status and cause of death were ascertained and compared with expectations based upon national mortality rates by computing standardized mortality ratios (SMRs) overall and by categories of time since first hire, calendar period of first employment and duration of employment as a miner. Results There were 51 787 deaths observed among 118 329 male miners [SMR = 1.05; 95% confidence interval (CI): 1.04, 1.06]. The SMR was elevated for all cancers (n = 16 633, SMR = 1.23; 95% CI: 1.21, 1.25), due primarily to excess mortality from cancers of the lung (n = 7756, SMR = 1.90; 95% CI: 1.86, 1.94), liver and gallbladder (n = 549, SMR = 1.15; 95% CI: 1.06, 1.25), larynx (n = 229, SMR = 1.10; 95% CI: 0.97, 1.26), stomach (n = 1058, SMR = 1.08; 95% CI: 1.02, 1.15) and pleura (n = 39, SMR = 1.06; 95% CI: 0.75, 1.44). Lung-cancer SMRs increased with duration of employment, decreased with calendar period and persisted with time since first hire. Among non-malignant causes, the SMR was elevated for external causes (n = 3362, SMR = 1.41; 95% CI: 1.36, 1.46) and respiratory diseases (n = 4508, SMR = 1.32; 95% CI: 1.28, 1.36), most notably silicosis (n = 814, SMR = 13.56; 95% CI: 12.64, 14.52), but not chronic obstructive pulmonary disease (n = 1729, SMR = 0.98; 95% CI: 0.93, 1.02). Conclusions Whereas there are important obstacles to the ability to detect adverse effects of occupational exposures via SMR analyses, PUMA provides evidence of excess mortality among uranium miners due to a range of categories of cause of death. The persistent elevation of SMRs with time since first hire as a uranium miner underscores the importance of long-term follow-up of these workers. |
| تدمد: | 0300-5771 1464-3685 |
| DOI: | 10.1093/ije/dyaa195⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182106539ed8f83af0f319b60df91be https://escholarship.org/uc/item/7dw1p1dx |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3182106539ed8f83af0f319b60df91be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03005771 14643685 |
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| DOI: | 10.1093/ije/dyaa195⟩ |