Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
| العنوان: | Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28 |
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| المؤلفون: | Deepa Ravindra, Xinbei Li, William T. Mills, Mollie K. Meffert, Noor N. Nassar |
| المصدر: | Cells, Vol 9, Iss 2710, p 2710 (2020) Cells |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Lin28, RNA-binding protein, Review, Biology, LIN28, NF-κB, transcription factor, NF-κB, let-7 microRNA, chemistry.chemical_compound, microRNA, Animals, Humans, lcsh:QH301-705.5, Transcription factor, transcription factor, Cell survival, Progenitor, Neurons, neurodevelopment, Stem Cells, nervous system, NF-kappa B, RNA-Binding Proteins, General Medicine, pluripotency, Cell biology, MicroRNAs, lcsh:Biology (General), chemistry, nervous system, RNA-binding protein, Function (biology), Signal Transduction, Transcription Factors |
| الوصف: | An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation. |
| تدمد: | 2073-4409 |
| DOI: | 10.3390/cells9122710 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317ee5c5ffdfecda941a698e009bae61 https://doi.org/10.3390/cells9122710 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....317ee5c5ffdfecda941a698e009bae61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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| DOI: | 10.3390/cells9122710 |