Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial
| العنوان: | Early nasojejunal tube feeding versus nil-by-mouth in acute pancreatitis: A randomized clinical trial |
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| المؤلفون: | Goran Poropat, Neven Franjić, Davor Štimac, Goran Hauser, Vanja Licul, Sandra Milić, P. Valkovic Zujic |
| المصدر: | Pancreatology Volume 16 Issue 4 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, complications, fasting, Multiple Organ Failure, Endocrinology, Diabetes and Metabolism, acute necrotizing pancreatitis, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, enteral nutrition, mortality, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Adverse effect, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Aged, Aged, 80 and over, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, Hepatology, Pancreatitis, Acute Necrotizing, business.industry, Gastroenterology, Length of Stay, Middle Aged, medicine.disease, Systemic Inflammatory Response Syndrome, Surgery, Systemic inflammatory response syndrome, Regimen, Jejunum, Treatment Outcome, Parenteral nutrition, 030220 oncology & carcinogenesis, Acute pancreatitis, Pancreatitis, Female, 030211 gastroenterology & hepatology, Nasal Cavity, business |
| الوصف: | BACKGROUND/OBJECTIVES: There is substantial evidence of superiority of enteral nutrition (EN) to parenteral nutrition in acute pancreatitis (AP) treatment, but few studies evaluated its effectiveness compared to no intervention. The objective of our trial was to compare the effects of EN to a nil-by-mouth (NBM) regimen in patients with AP. METHODS: Patients with AP were randomized to receive either EN via a nasojejunal tube initiated within 24 h of admission or no nutritional support. Systemic inflammatory response syndrome (SIRS) was assessed as the primary outcome. Secondary outcomes included mortality, organ failure, local complications, infected pancreatic necrosis, surgical interventions, length of hospital stay, adverse events and inflammatory response intensity. Outcomes were compared using Student's t-test and Mann- Whitney U test as appropriate. RESULTS: 214 patients were randomized in total, 107 to each group. SIRS occurrence was similar between groups, with 48 (45%) versus 51 (48%), respectively (RR 0.94 ; 95% CI 0.71-1.26). No significant reduction of persistent organ failure (RR 0.81 ; 95% CI 0.52-1.27) and mortality (RR 0.59 ; 95% CI 0.28-1.23) was present in the EN group. There were no significant differences in other outcomes between the groups. When analyzing the occurrence of SIRS and mortality in subgroup of patients with severe disease no significant differences were noted. CONCLUSION: Our results showed no significant reduction of persistent organ failure and mortality in patients with AP receiving early EN compared to patients treated with no nutritional support (NCT01965873). |
| وصف الملف: | application/pdf |
| تدمد: | 1424-3903 |
| DOI: | 10.1016/j.pan.2016.04.003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a79302bc6cd5f984ca5ce02c6d5fd0 https://doi.org/10.1016/j.pan.2016.04.003 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....30a79302bc6cd5f984ca5ce02c6d5fd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14243903 |
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| DOI: | 10.1016/j.pan.2016.04.003 |