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Application and mechanism of manganese-coated caramelization nanospheres for active targeting in hepatobiliary tumors

التفاصيل البيبلوغرافية
العنوان: Application and mechanism of manganese-coated caramelization nanospheres for active targeting in hepatobiliary tumors
المؤلفون: Xiao-ming Zhang, Yafei Qi, Mingquan Zhu, Ying Xiang, Jiayang Fang, Wenqin Li, Dexin Yu, Xiangxing Ma, Qing Wang, Jinhua Zhan
المصدر: Nanomedicine (London, England). 14(22)
سنة النشر: 2019
مصطلحات موضوعية: Cell type, Cell Survival, media_common.quotation_subject, Biomedical Engineering, Medicine (miscellaneous), chemistry.chemical_element, Contrast Media, Bioengineering, 02 engineering and technology, Manganese, Development, 030218 nuclear medicine & medical imaging, Excretion, 03 medical and health sciences, Mice, 0302 clinical medicine, Microscopy, Electron, Transmission, Macrophage, Animals, Humans, General Materials Science, Cytotoxicity, Internalization, media_common, Microscopy, Confocal, Macrophages, Metabolism, Hep G2 Cells, 021001 nanoscience & nanotechnology, Magnetic Resonance Imaging, Caramelization, Rats, RAW 264.7 Cells, chemistry, Liver, Cancer research, Hepatocytes, 0210 nano-technology, Nanospheres
الوصف: Aim: To elucidate the MRI mechanisms of manganese oxide-coated carbohydration nanosphere (Mn@CNS) for active targeting in hepatobiliary tumors. Materials & methods: The cytotoxicity, internalization pathway, metabolism and excretion pathway of Mn@CNS were assessed by several cell types. The MRI of Mn@CNS was verified via rat models bearing hepatobiliary tumors. Results: Mn@CNS showed no obvious cytotoxicity. Mice macrophage and hepatocellular Mn content significantly differed between pre- and post-uptake levels (p
تدمد: 1748-6963
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3089477cebb985a17b9c3d895379be15
https://pubmed.ncbi.nlm.nih.gov/31793384
رقم الانضمام: edsair.doi.dedup.....3089477cebb985a17b9c3d895379be15
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17486963