Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin
| العنوان: | Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin |
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| المؤلفون: | Melina E. Hale, Alexander Roche, Katharine W Henderson, Evdokia Menelaou |
| المصدر: | Frontiers in Neuroanatomy, Vol 14 (2020) Frontiers in Neuroanatomy |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Nervous system, neuroanatomy, rohon-beard, pectoral fins, Neuroscience (miscellaneous), Hindbrain, Sensory system, Biology, lcsh:RC321-571, lcsh:QM1-695, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Fish fin, lcsh:Human anatomy, Anatomy, zebrafish, Spinal cord, Sensory neuron, 030104 developmental biology, medicine.anatomical_structure, sensory systems, nervous system, Neuron, Cutaneous innervation, 030217 neurology & neurosurgery |
| الوصف: | Vertebrate forelimbs contain arrays of sensory neuron fibers that transmit signals from the skin to the nervous system. We used the genetic toolkit and optical clarity of the larval zebrafish to conduct a live imaging study of the sensory neurons innervating the pectoral fin skin. Sensory neurons in both the hindbrain and the spinal cord innervate the fin, with most cells located in the hindbrain. The hindbrain somas are located in rhombomere seven/eight, laterally and dorsally displaced from the pectoral fin motor pool. The spinal cord somas are located in the most anterior part of the cord, aligned with myomere four. Single cell reconstructions were used to map afferent processes and compare the distributions of processes to soma locations. Reconstructions indicate that this sensory system breaks from the canonical somatotopic organization of sensory systems by lacking a clear organization with reference to fin region. Arborizations from a single cell branch widely over the skin, innervating the axial skin, lateral fin surface, and medial fin surface. The extensive branching over the fin and the surrounding axial surface suggests that these fin sensory neurons report on general conditions of the fin area rather than providing fine location specificity, as has been demonstrated in other vertebrate limbs. With neuron reconstructions that span the full primary afferent arborization from the soma to the peripheral cutaneous innervation, this neuroanatomical study describes a system of primary sensory neurons and lays the groundwork for future functional studies. |
| تدمد: | 1662-5129 |
| DOI: | 10.3389/fnana.2020.581821 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308894b9e93d8aff71104fb026ea3b6d https://doi.org/10.3389/fnana.2020.581821 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....308894b9e93d8aff71104fb026ea3b6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16625129 |
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| DOI: | 10.3389/fnana.2020.581821 |