Chronodisruption by chronic jetlag impacts metabolic and gastrointestinal homeostasis in male mice
| العنوان: | Chronodisruption by chronic jetlag impacts metabolic and gastrointestinal homeostasis in male mice |
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| المؤلفون: | Anneleen Segers, Kristin Verbeke, Inge Depoortere, Theo Thijs, Louis Desmet |
| المصدر: | Acta Physiologica. 233 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | gastrointestinal hormones, Male, 0301 basic medicine, medicine.medical_specialty, Colon, Physiology, short-chain fatty acids, Circadian clock, Stimulation, Arntl Knock Out, 030204 cardiovascular system & hematology, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Circadian Clocks, Internal medicine, circadian clock, medicine, Animals, Homeostasis, Tight junction, chronic jetlag, digestive, oral, and skin physiology, Feeding Behavior, Proglucagon, Fatty Acids, Volatile, Circadian Rhythm, CLOCK, 030104 developmental biology, Endocrinology, colonic crypts, Tumor necrosis factor alpha, Ghrelin |
| الوصف: | AIM: Chronodisruption desynchronizes peripheral clocks and leads to metabolic diseases. Feeding cues are important synchronizers of peripheral clocks and influence rhythmic oscillations in intestinal microbiota and their metabolites. We investigated whether chronic jetlag, mimicking frequent time zone travelling, affected the diurnal fluctuations in faecal short-chain fatty acid (SCFA) levels, that feed back to the gut clock to regulate rhythmicity in gut function. METHODS: Rhythms in faecal SCFAs levels and in the expression of clock genes and epithelial markers were measured in the colonic mucosa of control and jetlagged mice. The entraining effect of SCFAs on the rhythm in clock gene mRNA expression was studied in primary colonic crypts. The role of the circadian clock in epithelial marker expression was studied in Arntl-/- mice. RESULTS: Chronic jetlag increased body weight gain and abolished the day/night food intake pattern which resulted in a phase-delay in the rhythm of faecal SCFAs that paralleled the shift in the expression of mucosal clock genes. This effect was mimicked by stimulation of primary colonic crypts from control mice with SCFAs. Jetlag abolished the rhythm in Tnfα, proglucagon and ghrelin expression but not in the expression of tight junction markers. Only a dampening in plasma glucagon-like peptide-1 but not in ghrelin levels was observed. Rhythms in ghrelin but not proglucagon mRNA expression were abolished in Arntl-/- mice. CONCLUSION: The altered food intake pattern during chronodisruption corresponds with the changes in rhythmicity of SCFA levels that entrain clock genes to affect rhythms in mRNA expression of gut epithelial markers. ispartof: ACTA PHYSIOLOGICA vol:233 issue:4 ispartof: location:England status: published |
| وصف الملف: | Print-Electronic |
| تدمد: | 1748-1716 1748-1708 |
| DOI: | 10.1111/apha.13703 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30858faaa11651a7172971b0604023ad https://doi.org/10.1111/apha.13703 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30858faaa11651a7172971b0604023ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17481716 17481708 |
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| DOI: | 10.1111/apha.13703 |