Congenital Hypothyroidism and Bone Remodeling Cycle
| العنوان: | Congenital Hypothyroidism and Bone Remodeling Cycle |
|---|---|
| المؤلفون: | M Ağah Tekindal, Sibel Tulgar Kinik, Nursel Muratoglu Sahin, Beril Özdemir, Ayşegül Haberal, Nazmi Mutlu Karakaş |
| المصدر: | Journal of Clinical Research in Pediatric Endocrinology |
| بيانات النشر: | Galenos Publishing, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Bone remodeling period, bone marker, Male, medicine.medical_specialty, endocrine system, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Bone resorption, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, thyroxin, 030225 pediatrics, Internal medicine, Vitamin D and neurology, medicine, Humans, Vitamin D, Child, Bone Density Conservation Agents, business.industry, Tartrate-Resistant Acid Phosphatase, Thyroid, congenital hypothyroidism, medicine.disease, Peptide Fragments, Congenital hypothyroidism, Procollagen peptidase, Thyroxine, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Original Article, Female, Bone Remodeling, business, Biomarkers, Procollagen, Hormone, Follow-Up Studies |
| الوصف: | Objective: The present study aimed to evaluate the biochemical markers of bone turnover in children with congenital hypothyroidism during the course of treatment as compared to healthy children selected as controls. Methods: The study included 31 children with congenital hypothyroidism and 29 healthy children. In both groups, we evaluated serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels as bone turnover markers. Results: In both groups, thyroid hormone levels were within normal limits. The levels of vitamin D were significantly higher in the cases with congenital hypothyroidism. Although PINP levels were not found to be different, TRACP 5b levels which are related to osteoclastic activities were significantly higher in the control group. Conclusion: We did not detect an increase in bone resorption in patients with congenital hypothyroidism, despite long-term treatment with LT4. Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1308-5735 1308-5727 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307675738e9e0037f5eb7db54fa3f031 http://europepmc.org/articles/PMC5463281 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....307675738e9e0037f5eb7db54fa3f031 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13085735 13085727 |
|---|