Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability
| العنوان: | Environmental radiation on large Japanese field mice in Fukushima reduced colony forming potential in hematopoietic progenitor cells without inducing genomic instability |
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| المؤلفون: | Akifumi Nakata, Carmel Mothersill, Hideaki Yamashiro, Valerie Swee Ting Goh, Yohei Fujishima, Mitsuaki A. Yoshida, Kosuke Kasai, Tomisato Miura, Hisashi Shinoda, Kentaro Ariyoshi, Yoshinaka Shimizu, Colin Seymour, Atsushi Takahashi |
| المصدر: | International Journal of Radiation Biology. 98:1147-1158 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Genome instability, Radiological and Ultrasound Technology, biology, Arvicolinae, Radiation, Hematopoietic Stem Cells, biology.organism_classification, Radiation effect, Genomic Instability, 030218 nuclear medicine & medical imaging, Cell biology, Mice, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, embryonic structures, Animals, Fukushima Nuclear Accident, Hematopoietic progenitor cells, Radiology, Nuclear Medicine and imaging, Murinae, Apodemus speciosus |
| الوصف: | To study the environmental radiation effects of wild animals after the Fukushima Dai-ichi nuclear power plant accident, we assessed effects on hematopoietic progenitor cells (HPCs) in large Japanese field mice (A. speciosus were collected from three contaminated sites and control area. The air dose-rates at the control and contaminated areas were 0.96 ± 0.05 μGy/d (Hirosaki), 14.4 ± 2.4 μGy/d (Tanashio), 208.8 ± 31.2 μGy/d (Ide), 470.4 ± 93.6 μGy/d (Omaru), respectively. We investigated possible DNA damage and pro-inflammatory markers in the bone marrow (BM) cells. The colony-forming potential of BM cells was estimated by the number of HPC colony-forming cells. Radiation-induced genomic instability (RIGI) in HPCs was also analyzed by quantifying delayed DNA damage in CFU-GM clones.Although no significant differences in DNA damage and inflammation markers in BM cells from control and contaminated areas, the number of HPC colonies exhibited an inverse correlation with air dose-rate. With regard to RIGI, no significant differences in DNA damage of CFU-GM clones between the mice from the control and the three contaminated areas.Our study suggests that low dose-rate radiation of more than 200 Gy/d reduced HPCs, possibly eliminating genomically unstable HPCs. |
| تدمد: | 1362-3095 0955-3002 |
| DOI: | 10.1080/09553002.2020.1807643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306250ce27516e0cafe3cb95338a625a https://doi.org/10.1080/09553002.2020.1807643 |
| رقم الانضمام: | edsair.doi.dedup.....306250ce27516e0cafe3cb95338a625a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13623095 09553002 |
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| DOI: | 10.1080/09553002.2020.1807643 |