Preventive versus 'on-demand' nutritional support during antiviral treatment for hepatitis C: A randomized controlled trial
| العنوان: | Preventive versus 'on-demand' nutritional support during antiviral treatment for hepatitis C: A randomized controlled trial |
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| المؤلفون: | Bart van Hoek, Joop E. Arends, Karin M.J. van Nieuwkerk, Hanneke van Soest, Peter D. Siersema, Ellen J. Huisman, Karel J. van Erpecum |
| المساهمون: | Gastroenterology and hepatology, CCA - Innovative therapy |
| المصدر: | Huisman, E J, van Hoek, B, van Soest, H, van Nieuwkerk, C M J, Arends, J E, Siersema, P D & Erpecum, K J 2012, ' Preventive versus "on-demand" nutritional support during antiviral treatment for hepatitis C: A randomized controlled trial ', Journal of Hepatology, vol. 57, no. 5, pp. 1069-1075 . https://doi.org/10.1016/j.jhep.2012.06.029 Journal of Hepatology, 57(5), 1069-1075. Elsevier Journal of Hepatology, 57(5), 1069-1075 |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Quality of life, medicine.medical_specialty, Weight loss, Digestive System Diseases, Nutritional Status, Interferon alpha-2, Antiviral therapy, Antiviral Agents, Digestive symptoms, law.invention, Polyethylene Glycols, chemistry.chemical_compound, Grip strength, Randomized controlled trial, law, Internal medicine, Ribavirin, Clinical endpoint, Medicine, Humans, Medical nutrition therapy, Nutritional support, Aged, Hepatology, Hand Strength, business.industry, Protein, Malnutrition, Interferon-alpha, Hepatitis C, Middle Aged, medicine.disease, Recombinant Proteins, Treatment Outcome, chemistry, Physical therapy, Female, Nutrition Therapy, medicine.symptom, business, Digestive System |
| الوصف: | Although antiviral treatment for hepatitis C (HCV) is highly effective, side effects often occur, including weight loss, digestive symptoms, and impaired quality of life. We aimed at exploring the beneficial effects of preventive nutritional support.In a randomized controlled trial, 53 HCV patients were allocated to "on demand" support (n=26: nutritional intervention if weight loss5%) or preventive support (n=27: regular dietary advice plus energy- and protein-rich evening snack). Nutritional state (including validated Jamar Hand Grip Strength), digestive symptoms (visual analog score), and quality of life (SF-36 survey) were evaluated at baseline, and after 24 and 48 weeks of peginterferon α-2b and ribavirin treatment.The primary end point (weight loss at 24 weeks) was reached in 22 patients in both groups. Weight decreased markedly in the "on demand" group (decrease at 24 weeks: 5.4 kg or 6.9%, p0.001), but not in the preventive group (decrease 0.3 kg or 0.3%, p=n.s.). Jamar Hand Grip Strength deteriorated in the "on demand" group (from 40.3 ± 15.5 kg to 32.0 ± 13.1 kg, p0.001) but not in the preventive group (from 40.7 ± 10.4 kg to 39.7 ± 8.9 kg, p=n.s.). Intake of energy, proteins, and fat decreased markedly in the "on demand" group but increased in the preventive group. Although digestive symptoms and quality of life deteriorated, impairment was significantly less in the preventive group.Preventive nutritional advice plus supplementation prevents weight loss and catabolic state during HCV antiviral therapy, with improved digestive symptoms and quality of life. |
| تدمد: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2012.06.029 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe13746431f2eb532573c1a9dd1f9be https://research.vumc.nl/en/publications/2dc28a8d-3253-43db-8372-d4d67253228d |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2fe13746431f2eb532573c1a9dd1f9be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01688278 |
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| DOI: | 10.1016/j.jhep.2012.06.029 |