Correction to: Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis

التفاصيل البيبلوغرافية
العنوان: Correction to: Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis
المؤلفون: Shi xun Lu, Ai Jun Zhou, Shi Bing Li, Yong Du, Ning Xue, Yan Li, Zhi ping Zhao, Da nian Dai, Wei dong Wei, Bo Chen, Mu Sheng Zeng, Tian Liang Xia, Qian Zhong
بيانات النشر: Springer Berlin Heidelberg, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Poor prognosis, Cell Survival, MEDLINE, Breast Neoplasms, Cell Line, Breast cancer, Cell Movement, Internal medicine, Cell Line, Tumor, Drug Discovery, medicine, Humans, RNA, Small Interfering, Genetics (clinical), business.industry, Correction, medicine.disease, Prognosis, Molecular medicine, Human genetics, Expression (architecture), Molecular Medicine, Salivary Cystatins, Female, business
الوصف: Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the prognostic significance and function of CST1 in breast cancer remains unknown. In the current study, we found that CST1 was generally upregulated in breast cancer at both mRNA and protein level. Furthermore, overall survival (OS) and disease-free survival (DFS) in the low CST1 expression subgroup were significantly superior to the high CST1 expression subgroup (OS, p 0.001; DFS, p 0.001), which indicated that CST1 expression level was closely correlated to the survival risk of these patients. Univariate and multivariate analyses demonstrated that CST1 expression was an independent prognostic factor, the same as ER status and nodal status. Next, CST1 overexpression promoted breast cancer cell proliferation, clonogenicity, migration, and invasion abilities. By contrast, knockdown of CST1 attenuated these malignant characteristics in breast cancer cells. Collectively, our study indicates that CST1 cannot only serve as a significant prognostic indicator but also as a potential therapeutic target for breast cancer.High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer.
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc91a434a9205a1e6a595313650a8e8
https://europepmc.org/articles/PMC6828270/
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....2fc91a434a9205a1e6a595313650a8e8
قاعدة البيانات: OpenAIRE