Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function
| العنوان: | Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function |
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| المؤلفون: | Alessandra Medeiros, P. C. Brum, Julio C.B. Ferreira, Aline Villa Nova Bacurau, Andrea Somolanji Vanzelli, Carlos Eduardo Negrão |
| المساهمون: | Universidade de São Paulo (USP), Universidade Federal de São Paulo (UNIFESP), Stanford Univ |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| بيانات النشر: | FapUNIFESP (SciELO), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cardiac function curve, Sympathetic nervous system, medicine.medical_specialty, Sympathetic Nervous System, Physiology, Immunology, Biophysics, Heart failure, Disease, Biochemistry, Exercise training, Mice, Physical Conditioning, Animal, Internal medicine, medicine, Animals, Humans, Ventricular Function, Aerobic exercise, General Pharmacology, Toxicology and Pharmaceutics, Exercise physiology, Muscle, Skeletal, Ventricular remodeling, Exercise, Ventricular function, Skeletal myopathy, Cardiac remodeling, Heart Failure, Exercise Tolerance, Ventricular Remodeling, business.industry, General Neuroscience, CARDIOLOGIA, Skeletal muscle, Heart, Cell Biology, General Medicine, medicine.disease, Sympathetic hyperactivity, medicine.anatomical_structure, Cardiology, Physical therapy, business |
| الوصف: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training. Univ Sao Paulo, Dept Biodinam Movimento Corpo Humano, Escola Educ Fis & Esporte, BR-05508900 Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil Stanford Univ, Dept Chem & Syst Biol, Palo Alto, CA 94304 USA Univ Sao Paulo, Fac Med, Inst Coracao, BR-05508900 Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil FAPESP: 2002/04558-8 FAPESP: 2005/59740-7 FAPESP: 2006/61523-7 FAPESP: 2008/50777-3 FAPESP 2009/03143-1 CNPq: 473251/2009-4 CNPq: BPQ 301519/2008-0 Web of Science |
| تدمد: | 0100-879X |
| DOI: | 10.1590/s0100-879x2011007500075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa70b5044a0bbf155054e54841844e8 https://doi.org/10.1590/s0100-879x2011007500075 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2fa70b5044a0bbf155054e54841844e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0100879X |
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| DOI: | 10.1590/s0100-879x2011007500075 |