Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review
| العنوان: | Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review |
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| المؤلفون: | Kenneth Croitoru, Bhupesh Kumar Thakur, Thergiory Irrazabal, Alberto Martin |
| المصدر: | Cellular and Molecular Gastroenterology and Hepatology Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1177-1197 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, HFD, high-fat diet, Antioxidant, Colorectal cancer, medicine.medical_treatment, Review, Inflammatory bowel disease, Antioxidants, 0302 clinical medicine, AOM, azoxymethane, CAC, colitis-associated colon cancer, DSS, dextran sodium sulfate, IBD, inflammatory bowel disease, vitC, vitamin C, GSTTT1, glutathione-S-transferase theta 1, Gastroenterology, 8-oxoG, 8-oxo-7,8-dihydro-2′-deoxyguanosine, Colitis, 3. Good health, NAC, N-acetylcysteine, NOX, nicotinamide adenine dinucleotide phosphate oxidase, CRC, colorectal cancer, 030211 gastroenterology & hepatology, medicine.symptom, DNA damage, Inflammation, Context (language use), MMR, mismatch repair, H2O2, hydrogen peroxidase, vitE, vitamin E, 03 medical and health sciences, ROS, reactive oxygen species, mtROS, mitochondrial ROS, SOD, superoxide dismutase, Gpx, glutathione peroxidase, GST, glutathione-S-transferase, medicine, PRDX, peroxiredoxin, RNI, reactive nitrogen intermediaries, Animals, Humans, lcsh:RC799-869, Colorectal Cancer, DUOX2, dual oxidase 2, Hepatology, business.industry, Inflammatory Bowel Disease, medicine.disease, AT1, angiotensin II type 1, digestive system diseases, Review article, O2•-, superoxide, UC, ulcerative colitis, 030104 developmental biology, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, CAT, catalase, Colitis-Associated Neoplasms, business, DNA Damage |
| الوصف: | Inflammatory bowel disease (IBD) patients have an increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Several studies have shown that IBD patients have signs of increased oxidative damage, which could be a result of genetic and environmental factors such as an excess in oxidant molecules released during chronic inflammation, mitochondrial dysfunction, a failure in antioxidant capacity, or oxidant promoting diets. It has been suggested that chronic oxidative environment in the intestine leads to the DNA lesions that precipitate colon carcinogenesis in IBD patients. Indeed, several preclinical and clinical studies show that different endogenous and exogenous antioxidant molecules are effective at reducing oxidation in the intestine. However, most clinical studies have focused on the short-term effects of antioxidants in IBD patients but not in CAC. This review article examines the role of oxidative DNA damage as a possible precipitating event in CAC in the context of chronic intestinal inflammation and the potential role of exogenous antioxidants to prevent these cancers. |
| اللغة: | English |
| تدمد: | 2352-345X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8c79d5f17568276f485aec45f7d118 http://europepmc.org/articles/PMC7907812 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f8c79d5f17568276f485aec45f7d118 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2352345X |
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