Genetic factors associated with obesity risks in a Kazakhstani population
| العنوان: | Genetic factors associated with obesity risks in a Kazakhstani population |
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| المؤلفون: | Alpamys Issanov, Mei-Yen Chan, Chee Kai Chan, Ainur Akilzhanova, Ulan Kozhamkulov, Robbie Chan, Dauren Yerezhepov, Madina Razbekova |
| المصدر: | BMJ Nutrition, Prevention & Health BMJ Nutrition, Prevention & Health, Vol 4, Iss 1 (2021) |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, RC620-627, Health (social science), Population, Medicine (miscellaneous), 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Disease, Overweight, Logistic regression, metabolic syndrome, 03 medical and health sciences, 0302 clinical medicine, medicine, Nutritional diseases. Deficiency diseases, education, precision nutrition, Original Research, education.field_of_study, Nutrition and Dietetics, business.industry, Confounding, medicine.disease, Obesity, 030104 developmental biology, Metabolic syndrome, medicine.symptom, business, Demography |
| الوصف: | ObjectivesThere is limited published literature on the genetic risks of chronic inflammatory related disease (eg, obesity and cardiovascular disease) among the Central Asia population. The aim is to determine potential genetic loci as risk factors for obesity for the Kazakhstani population.SettingKazakhstan.ParticipantsOne hundred and sixty-three Kazakhstani nationals (ethnic groups: both Russians and Kazakhs) were recruited for the cross-sectional study. Linear regression models, adjusted for confounding factors, were used to examine the genetic associations of single nucleotide polymorphisms (SNPs) in 19 genetic loci with obesity (73 obese/overweight individuals and 90 controls).ResultsOverall, logistic regression analyses revealed genotypes C/T in CRP (rs1205), A/C in AGTR1 (rs5186), A/G in CBS (rs234706), G/G in FUT2 (rs602662), A/G in PAI-1 (rs1799889), G/T (rs1801131) and A/G (rs1801133) in MTHFR genes significantly decrease risk of overweight/obesity. After stratification for ethnicity, rs234706 was significantly associated with overweight/obesity in both Russians and Kazakhs, while rs1800871 was significant in Kazakhs only.ConclusionsThis study revealed that variations in SNPs known to be associated with cardiovascular health can also contribute to the risks of developing obesity in the population of Kazakhstan. |
| اللغة: | English |
| تدمد: | 2516-5542 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f26b5293f28d0800028256120bf5844 http://europepmc.org/articles/PMC8258080 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f26b5293f28d0800028256120bf5844 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25165542 |
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