Vesicoureteral reflux and the extracellular matrix connection
| العنوان: | Vesicoureteral reflux and the extracellular matrix connection |
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| المؤلفون: | Fatima Tokhmafshan, Patrick D. Brophy, Indra R. Gupta, Rasheed Gbadegesin |
| المصدر: | Pediatric Nephrology. 32:565-576 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Marfan syndrome, Pathology, medicine.medical_specialty, 030232 urology & nephrology, Connective tissue, urologic and male genital diseases, Vesicoureteral reflux, Article, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Ureter, Humans, Medicine, Child, Vesico-Ureteral Reflux, business.industry, medicine.disease, female genital diseases and pregnancy complications, Extracellular Matrix, 030104 developmental biology, medicine.anatomical_structure, Nephrology, Ehlers–Danlos syndrome, Pediatrics, Perinatology and Child Health, Ureterovesical Junction, business, Cutis laxa |
| الوصف: | Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes. |
| تدمد: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-016-3386-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebe9958280f4674bdeecf78f1a8626e https://doi.org/10.1007/s00467-016-3386-5 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2ebe9958280f4674bdeecf78f1a8626e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1432198X 0931041X |
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| DOI: | 10.1007/s00467-016-3386-5 |