PTK2 and PTPN11 expression in myelodysplastic syndromes
| العنوان: | PTK2 and PTPN11 expression in myelodysplastic syndromes |
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| المؤلفون: | Sara Teresinha Olalla Saad, Carolina L. Bigarella, Mariana Lazarini, Leticia Fröhlich Archangelo, Bruna Fernandes Mendes-Silva, João Agostinho Machado-Neto, Fabiola Traina |
| المصدر: | Clinics; v. 68 n. 10 (2013); 1371-1375 Clinics; Vol. 68 Núm. 10 (2013); 1371-1375 Clinics; Vol. 68 No. 10 (2013); 1371-1375 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 68, Iss 10, Pp 1371-1375 (2013) Clinics, Volume: 68, Issue: 10, Pages: 1371-1375, Published: OCT 2013 |
| بيانات النشر: | Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Phosphatase, PTK2, Bone Marrow Cells, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Biology, PTPN11, Polymerase Chain Reaction, Statistics, Nonparametric, src Homology Domains, Young Adult, Risk Factors, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, lcsh:R5-920, FAK, General Medicine, Focal Adhesion Kinase 2, Middle Aged, Prognosis, Endocrinology, medicine.anatomical_structure, Tyrosine kinase 2, Focal Adhesion Protein-Tyrosine Kinases, Myelodysplastic Syndromes, Cancer research, SHP2, Female, Bone marrow, lcsh:Medicine (General), Rapid Communication, Proto-oncogene tyrosine-protein kinase Src |
| الوصف: | OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| تدمد: | 1980-5322 1807-5932 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5cc4bd277263a780142f2acfb0eae4 https://www.revistas.usp.br/clinics/article/view/77016 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2e5cc4bd277263a780142f2acfb0eae4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19805322 18075932 |
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