Zebrafish embryos as models for embryotoxic and teratological effects of chemicals
| العنوان: | Zebrafish embryos as models for embryotoxic and teratological effects of chemicals |
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| المؤلفون: | Nga Yu Ho, Markus Reischl, Uwe Strähle, Ralf Mikut, Urban Liebel, Rüdiger Alshut, Jessica Legradi, Ferenc Müller, Carsten Weiss, Lixin Yang |
| المساهمون: | E&H: Environmental Health and Toxicology, Chemistry and Biology |
| المصدر: | Reproductive Toxicology; Vol 28 Yang, L, Ho, N Y, Alshut, R, Legradi, J B, Weiss, C, Reischl, M, Mikut, R, Liebel, U, Müller, F & Strähle, U 2009, ' Zebrafish embryos as models for embryotoxic and teratological effects of chemicals ', Reproductive Toxicology, vol. 28, no. 2, pp. 245-253 . https://doi.org/10.1016/j.reprotox.2009.04.013 Reproductive Toxicology, 28(2), 245-253. Elsevier Inc. |
| بيانات النشر: | Elsevier Inc., 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Toxicity Tests: methods, Embryo, Nonmammalian, Chemical compound, Xenobiotics: classification, Abnormalities, Drug-Induced,Abnormalities, Drug-Induced: etiology,Animal Testing Alternatives,Animals,Embryo, Nonmammalian,Embryo, Nonmammalian: drug effects,Genome,Models, Animal,Teratogens,Teratogens: classification,Teratogens: toxicity,Toxicity Tests,Toxicity Tests: methods,Xenobiotics,Xenobiotics: classification,Xenobiotics: toxicity,Zebrafish,Zebrafish: embryology,Zebrafish: physiology, 010501 environmental sciences, Toxicology, 01 natural sciences, Genome, chemistry.chemical_compound, Models, Drug-Induced: etiology, Zebrafish, 0303 health sciences, Nonmammalian, biology, Abnormalities, Drug-Induced, Embryo, Phenotype, Teratogens, Animal Testing Alternative, Models, Animal, embryonic structures, Abnormalities, animal structures, Transgene, Computational biology, Animal Testing Alternatives, Xenobiotics: toxicity, Xenobiotics, Zebrafish: physiology, 03 medical and health sciences, Toxicity Tests, Animals, Gene, 030304 developmental biology, 0105 earth and related environmental sciences, Teratogens: toxicity, Animal, biology.organism_classification, Teratogens: classification, Nonmammalian: drug effects, chemistry, Drug-Induced, etiology,Animal Testing Alternatives,Animals,Embryo, Nonmammalian,Embryo, Nonmammalian: drug effects,Genome,Models, Animal,Teratogens,Teratogens: classification,Teratogens: toxicity,Toxicity Tests,Toxicity Tests: methods,Xenobiotics,Xenobiotics: classification,Xenobiotics: toxicity,Zebrafish,Zebrafish: embryology,Zebrafish: physiology [Abnormalities, Drug-Induced,Abnormalities, Drug-Induced], Zebrafish: embryology |
| الوصف: | The experimental virtues of the zebrafish embryo such as small size, development outside of the mother, cheap maintenance of the adult made the zebrafish an excellent model for phenotypic genetic and more recently also chemical screens. The availability of a genome sequence and several thousand mutants and transgenic lines together with gene arrays and a broad spectrum of techniques to manipulate gene functions add further to the experimental strength of this model. Pioneering studies suggest that chemicals can have in many cases very similar toxicological and teratological effects in zebrafish embryos and humans. In certain areas such as cardiotoxicity, the zebrafish appears to outplay the traditional rodent models of toxicity testing. Several pilot projects used zebrafish embryos to identify new chemical entities with specific biological functions. In combination with the establishment of transgenic sensor lines and the further development of existing and new automated imaging systems, the zebrafish embryos could therefore be used as cost-effective and ethically acceptable animal models for drug screening as well as toxicity testing. |
| اللغة: | English |
| تدمد: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2009.04.013 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9f8792a81269d33f9c658f287525d8 https://research.vu.nl/en/publications/eeb93604-4491-4c47-b96c-3943379719b0 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....2d9f8792a81269d33f9c658f287525d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08906238 |
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| DOI: | 10.1016/j.reprotox.2009.04.013 |