Putative novel mediators of acute kidney injury in critically ill patients: handling by continuous venovenous hemofiltration and effect of anticoagulation modalities
| العنوان: | Putative novel mediators of acute kidney injury in critically ill patients: handling by continuous venovenous hemofiltration and effect of anticoagulation modalities |
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| المؤلفون: | Louise Schilder, Pieter M. ter Wee, Robert H.J. Beelen, Albertus Beishuizen, Armand R. J. Girbes, Nanne J. Paauw, S Azam Nurmohamed, A. B. Johan Groeneveld |
| المساهمون: | Pediatrics, Intensive Care, Nephrology, Intensive care medicine, Molecular cell biology and Immunology, ICaR - Circulation and metabolism |
| المصدر: | Schilder, L, Nurmohamed, S A, ter Wee, P M, Paauw, N J, Girbes, A R J, Beishuizen, A, Beelen, R H J & Groeneveld, A B J 2015, ' Putative novel mediators of acute kidney injury in critically ill patients: handling by continuous venovenous hemofiltration and effect of anticoagulation modalities ', BMC Nephrology, vol. 16, 178 . https://doi.org/10.1186/s12882-015-0167-5 BMC Nephrology BMC Nephrology, 16. BioMed Central Ltd. BMC Nephrology, 16:178. BioMed Central |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Nephrology, medicine.medical_specialty, Necrosis, Critical Care, Critical Illness, medicine.medical_treatment, Gastroenterology, Drug Administration Schedule, Young Adult, Critically ill patients, TWEAK, Internal medicine, Hemofiltration, medicine, Humans, Intensive care medicine, Aged, Pentraxin-3, Angiopioetin-2, Heparin, Critically ill, business.industry, Acute kidney injury, Anticoagulants, PTX3, Acute Kidney Injury, Middle Aged, medicine.disease, Combined Modality Therapy, Treatment Outcome, Continuous venovenous hemofiltration, Female, Inflammation Mediators, medicine.symptom, business, Citrate, Research Article, medicine.drug |
| الوصف: | Background: Novel putative mediators of acute kidney injury (AKI) include immune-cell derived tumour necrosis factor-like weak inducer of apoptosis (TWEAK), angiopoietin-2 (Ang-2) and protein pentraxin-3 (PTX3). The effect of continuous venovenous hemofiltration (CVVH) and different anticoagulation regimens on plasma levels were studied. Methods: At 0, 10, 60, 180 and 720 min of CVVH, samples were collected from pre- and postfilter blood and ultrafiltrate. No anticoagulation (n = 13), unfractionated heparin (n = 8) or trisodium citrate (n = 21) were compared. Results: Concentrations of TWEAK, Ang-2 and PTX3 were hardly affected by CVVH since the mediators were not (TWEAK, PTX3) or hardly (Ang-2) detectable in ultrafiltrate, indicating negligible clearance by the filter in spite of molecular sizes (TWEAK, PTX3) at or below the cutoff of the membrane. Heparin use, however, was associated with an increase in in-and outlet plasma TWEAK. Conclusion: Novel AKI mediators are not cleared nor produced by CVVH. However, heparin anticoagulation increased TWEAK levels in patient's plasma whereas citrate did not, favouring the latter as anticoagulant in CVVH for AKI. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2369 |
| DOI: | 10.1186/s12882-015-0167-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8ef653ee7bf7f24ad089da12b235af https://research.vumc.nl/en/publications/3a506d82-bbb4-41c3-9a81-764984813776 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d8ef653ee7bf7f24ad089da12b235af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712369 |
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| DOI: | 10.1186/s12882-015-0167-5 |