Role of hox genes in regulating digit patterning
| العنوان: | Role of hox genes in regulating digit patterning |
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| المؤلفون: | M F Bastida, Endika Haro, Marc Fernández-Guerrero, Rocío Pérez-Gómez, Maria A. Ros |
| المساهمون: | Ministerio de Economía y Competitividad (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Universidad del País Vasco, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Embryology, animal structures, Regulator, Gli3, Shh, 03 medical and health sciences, GLI3, Animals, Limb development, Hedgehog Proteins, Sonic hedgehog, Hox gene, Body Patterning, biology, Genes, Homeobox, Gene Expression Regulation, Developmental, Extremities, Numerical digit, Digit patterning, 030104 developmental biology, Hand Plate, Evolutionary biology, embryonic structures, biology.protein, Homeobox, Signal Transduction, Developmental Biology |
| الوصف: | The distal part of the tetrapod limb, the autopod, is characterized by the presence of digits. The digits display a wide diversity of shapes and number reflecting selection pressure for functional adaptation. Despite extensive study, the different aspects of digit patterning, as well as the factors and mechanisms involved are not completely understood. Here, we review the evidence implicating Hox proteins in digit patterning and the interaction between Hox genes and the Sonic hedgehog/Gli3 pathway, the other major regulator of digit number and identity. Currently, it is well accepted that a self-organizing Turing-type mechanism underlies digit patterning, this being understood as the establishment of an iterative arrangement of digit/interdigit in the hand plate. We also discuss the involvement of 5’ Hox genes in regulating digit spacing in the digital plate and therefore the number of digits formed in this self-organizing system. The M.A.R. laboratory is supported by the Spanish Ministerio de Economía, Industria y Competitividad (BFU2014-57216-P and BFU2017-88265-P). |
| تدمد: | 2014-5721 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d75d656f5dbb762f1de97c3c4d18c89 http://hdl.handle.net/10261/249059 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d75d656f5dbb762f1de97c3c4d18c89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20145721 |
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