The antinociceptive effects of estradiol on adjuvant-induced hyperalgesia in rats involve activation of adrenergic and serotonergic systems
| العنوان: | The antinociceptive effects of estradiol on adjuvant-induced hyperalgesia in rats involve activation of adrenergic and serotonergic systems |
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| المؤلفون: | Kentaro Okuda, Tetsuya Uchino, Satoshi Hagiwara, Takayuki Noguchi, Naozumi Takeshima, Hideo Iwasaka, Junji Takatani |
| المصدر: | Journal of Anesthesia. 25:392-397 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Serotonin, medicine.medical_specialty, Sympathetic Nervous System, Narcotic Antagonists, Freund's Adjuvant, Methysergide, (+)-Naloxone, Pharmacology, Serotonergic, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-2, Internal medicine, medicine, Animals, Serotonin receptor antagonist, Injections, Spinal, 5-HT receptor, Pain Measurement, Analgesics, Estradiol, Naloxone, business.industry, Yohimbine, Adrenergic alpha-2 Receptor Antagonists, Rats, Anesthesiology and Pain Medicine, Endocrinology, Opioid, Hyperalgesia, Anesthesia, Serotonin Antagonists, medicine.symptom, business, medicine.drug |
| الوصف: | Estradiol is a female hormone required for maintaining pregnancy and developing follicles in the ovary. Estradiol has been shown to perform a variety of physiological activities, including pain reduction. In this study, we tested the hypothesis that estradiol exerts antinociceptive effects in a rat model of inflammatory hyperalgesia. We established a subacute hyperalgesia model using plantar injection of Freund’s complete adjuvant (FCA) in Sprague–Dawley rats. We administered estradiol every 24 h, beginning 12 h after FCA administration, and used the plantar test to determine its effect on hyperalgesia. To determine the mechanism of action of estradiol, we evaluated the role of the opioid antinociceptive system using naloxone and the role of the descending pain inhibitory system using the α-2-receptor antagonist yohimbine and the serotonin receptor antagonist methysergide. Administration of FCA induced hyperalgesia, which was significantly reduced by estradiol treatment compared to controls. Moreover, this effect was not antagonized by naloxone, but was attenuated by α-2-receptor and serotonin-receptor antagonists. Estradiol is known to perform a variety of physiological functions. Our findings suggest that one such function is antinociception via an interaction with α-2 receptors and serotonin receptors. |
| تدمد: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-011-1142-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d20e25ee6c2f1d9a3683a471502facf https://doi.org/10.1007/s00540-011-1142-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....2d20e25ee6c2f1d9a3683a471502facf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14388359 09138668 |
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| DOI: | 10.1007/s00540-011-1142-3 |