Tumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast
| العنوان: | Tumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast |
|---|---|
| المؤلفون: | Miyuki, Hiratsuka, Takahiro, Hasebe, Yuki, Ichinose, Ayaka, Sakakibara, Akihiro, Fujimoto, Noriko, Wakui, Satomi, Shibasaki, Masataka, Hirasaki, Masanori, Yasuda, Akemi, Nukui, Hiroko, Shimada, Hideki, Yokogawa, Kazuo, Matsuura, Takashi, Hojo, Akihiko, Osaki, Toshiaki, Saeki |
| المصدر: | Virchows Archiv. 481:161-190 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Carcinoma, Humans, Breast Neoplasms, Female, Breast, Cell Biology, General Medicine, Neoplasm Grading, Fibrosis, Molecular Biology, Pathology and Forensic Medicine |
| الوصف: | Tumor budding grade is a very useful histological prognostic indicator for colorectal cancer patients. Recently, it has been also reported as a significant prognostic indicator in invasive breast carcinoma patients. Our group and others have previously reported that the presence of a fibrotic focus in the tumor is a very useful histological finding for accurately predicting the prognosis in patients with invasive carcinoma of no special type (ICNST) of the breast. The purpose of the present study was to investigate whether a grading system incorporating tumor budding in a fibrotic focus is superior to the conventional grading system for tumor budding to accurately predict outcomes in patients with ICNST. According to our new grading system, we classified the tumors into grade I (164 cases), grade II (581 cases), and grade III (110 cases), and the results clearly demonstrated the significant superiority of the new grading system over that of conventional tumor budding alone for accurately predicting outcomes in patients with ICNST. Our findings strongly suggest that tumor cells and tumor-stromal cells interaction play very important roles in tumor progression rather than tumor cells alone. |
| تدمد: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-022-03337-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce82fd5665f28291283b5aaab123e7e https://doi.org/10.1007/s00428-022-03337-0 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2ce82fd5665f28291283b5aaab123e7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322307 09456317 |
|---|---|
| DOI: | 10.1007/s00428-022-03337-0 |