Novel Insights into the Role of UBE3A in Regulating Apoptosis and Proliferation
| العنوان: | Novel Insights into the Role of UBE3A in Regulating Apoptosis and Proliferation |
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| المؤلفون: | Hanoch Kaphzan, Julia Panov, Olla Morsy, Lilach Simchi, Yonatan Feuermann |
| المصدر: | Journal of Clinical Medicine, Vol 9, Iss 1573, p 1573 (2020) Journal of Clinical Medicine; Volume 9; Issue 5; Pages: 1573 Journal of Clinical Medicine |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, RNA editing, congenital, hereditary, and neonatal diseases and abnormalities, Ubiquitin binding, Steroid hormone receptor, proliferation, lcsh:Medicine, Mitochondrion, Article, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Angelman syndrome, Coactivator, UBE3A, Medicine, biology, business.industry, lcsh:R, apoptosis, General Medicine, bioinformatics, medicine.disease, Cell biology, mitochondria, 030104 developmental biology, biology.protein, business, 030217 neurology & neurosurgery |
| الوصف: | The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning. Lack of UBE3A protein expression leads to Angelman syndrome (AS), while its overexpression is associated with autism. In spite of extensive research, our understanding of UBE3A roles is still limited. We investigated the cellular and molecular effects of Ube3a deletion in mouse embryonic fibroblasts (MEFs) and Angelman syndrome (AS) mouse model hippocampi. Cell cultures of MEFs exhibited enhanced proliferation together with reduced apoptosis when Ube3a was deleted. These findings were supported by transcriptome and proteome analyses. Furthermore, transcriptome analyses revealed alterations in mitochondria-related genes. Moreover, an analysis of adult AS model mice hippocampi also found alterations in the expression of apoptosis- and proliferation-associated genes. Our findings emphasize the role UBE3A plays in regulating proliferation and apoptosis and sheds light into the possible effects UBE3A has on mitochondrial involvement in governing this balance. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8a5f26ee9f930a99a96f989af29717 https://www.mdpi.com/2077-0383/9/5/1573 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c8a5f26ee9f930a99a96f989af29717 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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