Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis
| العنوان: | Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis |
|---|---|
| المؤلفون: | Lena A. von Schuckmann, B. Mark Smithers, M. Malt, Kiarash Khosrotehrani, Maria Celia B. Hughes, Adèle C. Green, Yahya Mahamat-Saleh, Kyoko Miura |
| المساهمون: | Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR) |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020, 29 (8), pp.1647-1653. ⟨10.1158/1055-9965.EPI-20-0319⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Epidemiology, Colorectal cancer, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Population, Gastroenterology, fatty acids, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Fatty Acids, Omega-6, Fatty Acids, Omega-3, medicine, Hyperinsulinemia, melanoma, Humans, education, 2. Zero hunger, chemistry.chemical_classification, education.field_of_study, (5): dietary patterns, omega-3 fatty acids, business.industry, Dietary intake, Insulin, Melanoma, medicine.disease, Confidence interval, omega-6 fatty acids, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Omega-6 fatty acid, Female, business, reduced rank regression |
| الوصف: | Background: Experimental evidence suggests that dietary intakes of omega-3 and omega-6 polyunsaturated fatty acids have divergent effects on melanoma growth, but epidemiologic evidence on their combined effect is lacking. Methods: In 634 Australian patients with primary melanoma, we assessed prediagnosis consumption of 39 food groups by food frequency questionnaires completed within 2 months of diagnosis. We derived, by reduced rank regression, dietary patterns that explained variability in selected omega-3 and omega-6 fatty acid intakes. Prevalence ratios (PR) and 95% confidence intervals (CI) for the association between tertiles of dietary patterns and melanoma thickness >2 mm versus ≤2 mm were estimated using Poisson regression. Results: Overall omega-3 fatty acid intakes were low. Two major fatty acid dietary patterns were identified: “meat, fish, and fat,” positively correlated with intakes of all fatty acids; and “fish, low-meat, and low-fat,” positively correlated with long-chain omega-3 fatty acid intake, and inversely with medium-chain omega-3 and omega-6 fatty acid intakes. Prevalence of thick melanomas was significantly higher in those in the highest compared with lowest tertile of the “meat, fish, and fat” pattern (PR, 1.40; 95% CI, 1.01–1.94), especially those with serious comorbidity (PR, 1.83; 95% CI, 1.15–2.92) or a family history (PR, 2.32; 95% CI, 1.00–5.35). The “fish, low-meat, and low-fat” pattern was not associated with melanoma thickness. Conclusions: People with high meat, fish, and fat intakes, who thus consumed relatively high levels of omega-3 and high omega-6 fatty acid intakes, are more likely to be diagnosed with thick than thin melanomas. Impact: High omega-3 and omega-6 fatty acid intakes may contribute to patients' presentation with thick melanomas. |
| اللغة: | English |
| تدمد: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-20-0319⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c87324bc0e59170e09b06664339b366 https://hal.archives-ouvertes.fr/hal-02938427 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c87324bc0e59170e09b06664339b366 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 |
|---|---|
| DOI: | 10.1158/1055-9965.EPI-20-0319⟩ |