Dibenzylxanthines as PPEPCK-M inhibitors for cancer therapy
| العنوان: | Dibenzylxanthines as PPEPCK-M inhibitors for cancer therapy |
|---|---|
| المؤلفون: | Belén Pérez, Jose C. Perales, Agnès Figueras, Sònia Abás, Petra Hyroššová, Sergio Rodríguez-Arévalo, Marc Aragó, Francesc Viñals, Juan Moreno, María Carmen Escolano |
| المصدر: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Proceedings, Vol 22, Iss 1, p 79 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | chemistry.chemical_classification, biology, Decarboxylation, Chemistry, Cancer therapy, lcsh:A, n/a, Enzyme, Biochemistry, Gluconeogenesis, biology.protein, Glyceroneogenesis, Citrate synthase, lcsh:General Works, Phosphoenolpyruvate carboxykinase |
| الوصف: | Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. In eukaryotes, there are two isozymes present either in the cytosol (PEPCKC, PCK1) or the mitochondria (PEPCK-M, PCK2). While PCK1 is found in gluconeogenic tissues and has a very clear metabolic function, PCK2 is expressed in non-gluconeogenic cell types, where its role remains largely unknown. For example, PCK2 is highly expressed in most cancer cells, where it provides a growth advantage to cancer cells in nutrient-poor environments. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4e063b1f3ba292295a862bc78d01cc https://ddd.uab.cat/record/217032 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c4e063b1f3ba292295a862bc78d01cc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |