Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking
| العنوان: | Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking |
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| المؤلفون: | Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, Ling Ding, Jingjie Tang, Artemis Kosta, Suzanne Giorgio, Richard Tomasini, Xing-Jie Liang, Nelson Dusetti, Juan Iovanna, Ling Peng |
| المساهمون: | Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Chinese Academy of Sciences [Beijing] (CAS), University of Chinese Academy of Sciences [Beijing] (UCAS), Institut de Microbiologie de la Méditerranée (IMM) |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, ⟨10.1073/pnas.2215308120⟩ |
| بيانات النشر: | HAL CCSD, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Multidisciplinary, [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, adaptive drug delivery, tumor-assisted drug delivery, dendrimer, extracellular vesicles |
| الوصف: | International audience; Drug delivery systems (DDSs) that can overcome tumor heterogeneity and achieve deep tumor penetration are challenging to develop yet in high demand for cancer treatment. We report here a DDS based on self-assembling dendrimer nanomicelles for effective and deep tumor penetration via in situ tumor-secreted extracellular vesicles (EVs), an endogenous transport system that evolves with tumor microenvironment. Upon arrival at a tumor, these dendrimer nanomicelles had their payload repackaged by the cells into EVs, which were further transported and internalized by other cells for delivery “in relay.” Using pancreatic and colorectal cancer-derived 2D, 3D, and xenograft models, we demonstrated that the in situ-generated EVs mediated intercellular delivery, propagating cargo from cell to cell and deep within the tumor. Our study provides a new perspective on exploiting the intrinsic features of tumors alongside dendrimer supramolecular chemistry to develop smart and effective DDSs to overcome tumor heterogeneity and their evolutive nature thereby improving cancer therapy |
| اللغة: | English |
| تدمد: | 0027-8424 1091-6490 |
| DOI: | 10.1073/pnas.2215308120⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2f9ec1023f599e5be9da271f556a8d https://hal.science/hal-03977439/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c2f9ec1023f599e5be9da271f556a8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 10916490 |
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| DOI: | 10.1073/pnas.2215308120⟩ |