New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment
| العنوان: | New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment |
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| المؤلفون: | Henrique Almeida, Sara Mendes, Elisabete Silva, Filipa Timóteo-Ferreira |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Uterus, Review Article, Biology, Endometrium, Biochemistry, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Placenta, medicine, Humans, lcsh:QH573-671, reproductive and urinary physiology, 030219 obstetrics & reproductive medicine, lcsh:Cytology, Myometrium, Placentation, Decidualization, Trophoblast, Cell Biology, General Medicine, Cell biology, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Female |
| الوصف: | For a successful pregnancy to occur, a predecidualized receptive endometrium must be invaded by placental differentiated cells (extravillous trophoblast cells (EVTs)) and, at the same time, continue decidualization. EVT invasion is aimed at anchoring the placenta to the maternal uterus and ensuring local blood supply increase necessary to provide normal placental and foetal development. The first is achieved by migrating through the maternal endometrium and deeper into the myometrium, while the second by transforming uterine spiral arteries into large vessels. This process is a tightly regulated battle comprising interests of both the mother and the foetus. Invading EVTs are required to perform a scope of functions: move, adhere, proliferate, differentiate, interact, and digest the extracellular matrix (ECM); tolerate hypoxia; transform the maternal spiral arteries; and die by apoptosis. All these functions are modulated by their surrounding microenvironment: oxygen, soluble factors (e.g., cytokines, growth factors, and hormones), ECM proteins, and reactive oxygen species. A deeper comprehension of oxidative uterine microenvironment contribution to trophoblast function will be addressed in this review. |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c04ede70b5663a1b761f9bcd08c9e18 https://doaj.org/article/9d80315a46ca436e8ee4772d2445a242 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c04ede70b5663a1b761f9bcd08c9e18 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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