Inmunoferon (Am3) Enhances the Activities of Early–Type Interferon Inducers and Natural Killer Cells
| العنوان: | Inmunoferon (Am3) Enhances the Activities of Early–Type Interferon Inducers and Natural Killer Cells |
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| المؤلفون: | Elena Baixeras, Antonio Portolés, José M. Rojo, E. Ronda, Monica Alonso, Isabel Barasoain, Pilar Moya |
| المساهمون: | Comisión Asesora de Investigación Científica y Técnica, CAICYT (España) |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Informa UK Limited, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Calcium Phosphates, Cytotoxicity, Immunologic, Lipopolysaccharides, Male, Drug, Interferon Inducers, media_common.quotation_subject, Immunology, Newcastle disease virus, Toxicology, Newcastle disease, Vesicular stomatitis Indiana virus, Virus, Mice, Interferon, In vivo, medicine, Animals, Immunology and Allergy, Inducer, Cytotoxicity, media_common, Pharmacology, Mice, Inbred BALB C, Interferon inducer, biology, Glycopeptides, General Medicine, biology.organism_classification, Killer Cells, Natural, Interferons, medicine.drug |
| الوصف: | The "in vivo" effect of Immunoferon (AM3) on the production of interferon (IFN) and natural killer (NK) activity in young and old mice was studied. Although AM3 is not an IFN inducer by itself, enhancements in the serum IFN levels were produced when drug was associated to Newcastle disease virus or bacterial lipopolysaccharides as IFN inducers. This effect appeared to be dependent on the time lapsed between the inducer agent and drug. In addition, a significant stimulating effect on NK cell activity was also produced by AM3 treatments. This effect could be a consequence of a marked IFN induction and/or a modifying effect in prostaglandin synthesis. This work was supported by a grant from CAICYT (num. 661-444/85 MEC; Spain). Authors thanks Mrs. M.L. del Pozo and Miss. M.C. Granados for their technical assistance, Mr. A. Hurtado for his drawing. Mr. E. Marquez's helpness for the data analysis in a computer program is also acknowledged. |
| تدمد: | 1532-2513 0892-3973 |
| DOI: | 10.3109/08923978709035213 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be5ff0507da3b0958de8891dd7d6823 https://doi.org/10.3109/08923978709035213 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2be5ff0507da3b0958de8891dd7d6823 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322513 08923973 |
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| DOI: | 10.3109/08923978709035213 |