Is There a Need for a More Precise Description of Biomolecule Interactions to Understand Cell Function?
| العنوان: | Is There a Need for a More Precise Description of Biomolecule Interactions to Understand Cell Function? |
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| المؤلفون: | Pierre Bongrand |
| المساهمون: | Bongrand, Pierre, Adhésion et Inflammation (LAI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Current Issues in Molecular Biology Current Issues in Molecular Biology, 2022, 44, pp.505-525. ⟨10.3390/cimb44020035⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), lymphocytes, [SDV] Life Sciences [q-bio], bond strengthening, [SDV]Life Sciences [q-bio], systems biology, General Medicine, artificial intelligence, catch bonds, Molecular Biology, Microbiology, molecular dynamics |
| الوصف: | International audience; An important goal of biological research is to explain and hopefully predict cell behavior from the molecular properties of cellular components. Accordingly, much work was done to build extensive “omic” datasets and develop theoretical methods, including computer simulation and network analysis to process as quantitatively as possible the parameters contained in these resources. Furthermore, substantial effort was made to standardize data presentation and make experimental results accessible to data scientists. However, the power and complexity of current experimental and theoretical tools make it more and more difficult to assess the capacity of gathered parameters to support optimal progress in our understanding of cell function. The purpose of this review is to focus on biomolecule interactions, the interactome, as a specific and important example, and examine the limitations of the explanatory and predictive power of parameters that are considered as suitable descriptors of molecular interactions. Recent experimental studies on important cell functions, such as adhesion and processing of environmental cues for decision-making, support the suggestion that it should be rewarding to complement standard binding properties such as affinity and kinetic constants, or even force dependence, with less frequently used parameters such as conformational flexibility or size of binding molecules. |
| وصف الملف: | application/pdf |
| تدمد: | 1467-3045 1467-3037 |
| DOI: | 10.3390/cimb44020035⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd3ef9451e655c78676814e4d24f0fc https://pubmed.ncbi.nlm.nih.gov/35723321 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2bd3ef9451e655c78676814e4d24f0fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb44020035⟩ |