Efficacy of SCH27899 in an Animal Model of Legionnaires' Disease Using Immunocompromised A/J Mice
| العنوان: | Efficacy of SCH27899 in an Animal Model of Legionnaires' Disease Using Immunocompromised A/J Mice |
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| المؤلفون: | Joan K. Brieland, Fred Menzel, David Loebenberg, Roberta S. Hare |
| المصدر: | Antimicrobial Agents and Chemotherapy. 44:1333-1336 |
| بيانات النشر: | American Society for Microbiology, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Ofloxacin, medicine.drug_class, medicine.medical_treatment, Antibiotics, Azithromycin, Biology, Legionella pneumophila, Macrolide Antibiotics, Immunocompromised Host, Mice, Anti-Infective Agents, medicine, Animals, Experimental Therapeutics, Pharmacology (medical), Lung, Pathogen, Antibacterial agent, Pharmacology, Immunosuppression, bacterial infections and mycoses, medicine.disease, biology.organism_classification, respiratory tract diseases, Anti-Bacterial Agents, Cortisone, Disease Models, Animal, Aminoglycosides, Infectious Diseases, Immunology, Female, Legionnaires' disease, Legionnaires' Disease, medicine.drug |
| الوصف: | Legionella pneumophila, the causative agent of Legionnaires' disease, is a facultative intracellular pathogen of mononuclear phagocytic cells (7, 9, 10). While all persons are susceptible to legionellosis, the frequency and severity of the disease are greatest in immunocompromised patients, with transplant recipients having the highest risk (2, 11). These patients frequently develop severe disseminated L. pneumophila infections, which may persist and/or recur despite antibiotic therapy (6). Furthermore, administration of antibiotics such as macrolides and rifampin, used to treat L. pneumophila-infected immunocompetent patients, may be contraindicated in similarly infected transplant patients, as these agents can alter the efficacy of drugs used to counter rejection (2). Therefore, identification of new antimicrobials which are effective against L. pneumophila infections in immunocompromised patients is needed. {"type":"entrez-protein","attrs":{"text":"SCH27899","term_id":"1052962409"}}SCH27899 is a newly described everninomicin antibiotic with a wide spectrum of activity against gram-positive bacteria, including methicillin-resistant staphylococci, vancomycin-resistant enterococci, and penicillin-resistant streptococci (R. S. Hare and F. J. Sabatelli, Abstr. 38th Intersci. Conf. Antimicrob. Agents Chemother., E-119, 1998). Recent in vitro studies using a cell-free system have demonstrated that {"type":"entrez-protein","attrs":{"text":"SCH27899","term_id":"1052962409"}}SCH27899 is also active against a narrow spectrum of gram-negative organisms, including L. pneumophila (4). However, the efficacy of {"type":"entrez-protein","attrs":{"text":"SCH27899","term_id":"1052962409"}}SCH27899 against L. pneumophila in vivo has not been assessed. We have previously developed a model of replicative L. pneumophila lung infection in immunocompetent A/J mice which mimics the pathogenesis of legionellosis in immunocompetent humans (1). Because immunosuppression induced by cortisone acetate (CA) predisposes humans to legionellosis, we hypothesized that CA administration to A/J mice would result in enhanced susceptibility to a severe replicative L. pneumophila infection. Furthermore, because of their small size (thereby requiring relatively little experimental compound), ease of handling, and low cost, we hypothesized that this model of legionellosis in CA-treated A/J mice would provide a valuable tool to evaluate the efficacy of antimicrobials, including {"type":"entrez-protein","attrs":{"text":"SCH27899","term_id":"1052962409"}}SCH27899, in the treatment of legionellosis in an immunocompromised host. |
| تدمد: | 1098-6596 0066-4804 1052-9624 |
| DOI: | 10.1128/aac.44.5.1333-1336.2000 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b648f6f0620175b37265de7ae886595 https://doi.org/10.1128/aac.44.5.1333-1336.2000 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2b648f6f0620175b37265de7ae886595 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 10529624 |
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| DOI: | 10.1128/aac.44.5.1333-1336.2000 |