Clinical course and risk factors for mortality from COVID‐19 in patients with haematological malignancies
| العنوان: | Clinical course and risk factors for mortality from COVID‐19 in patients with haematological malignancies |
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| المؤلفون: | Mari Liz Paciello, Rafael Feito Alonso, Antonia Rodriguez, Rodrigo Iñiguez, Rodrigo Gil Manso, Carolina Villegas, Nerea Castro Quismondo, Mario Rodríguez, Denis Zafra, José María Sánchez-Pina, Joaquin Martinez-Lopez, Xabier Gutierrez, María Poza, Rosa Ayala, María Dolores Folgueira, Gonzalo Carreño, Manuel Lizasoain, Cristina Garcia-Sanchez, Rafael Colmenares, José María Aguado, José Miguel Ferrari, Clara Cuellar, Daniel Gil Alos, María Calbacho, Irene Zamanillo, Rafael Delgado |
| المصدر: | European Journal of Haematology |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Lymphoma, medicine.medical_treatment, chemistry.chemical_compound, Tocilizumab, Risk Factors, Internal medicine, medicine, Humans, Viral shedding, Pandemics, Multiple myeloma, Aged, Aged, 80 and over, Chemotherapy, Hematology, biology, SARS-CoV-2, business.industry, Incidence (epidemiology), Mortality rate, C-reactive protein, Age Factors, COVID-19, Lopinavir, Retrospective cohort study, Hydroxychloroquine, Odds ratio, General Medicine, Middle Aged, Institutional review board, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, chemistry, Spain, Case-Control Studies, Hematologic Neoplasms, Multivariate Analysis, biology.protein, Female, Multiple Myeloma, business, Viral load, medicine.drug |
| الوصف: | Background: The impact of coronavirus disease 2019 (COVID-19) on hematological patients has not been comprehensively reported to date. Methods: We analyzed 39 hematological patients diagnosed with SARS-CoV-2 infection at our institution from March 7 to April 7, 2020. Clinical characteristics and outcomes were compared to a matched contemporary control group of 53 non-cancer patients hospitalized at our center. Univariate and multivariate analyses were carried out to assess the risk factors associated with poor outcome. Results: Median patient age was 64.7 years (range 36-88 years). The most frequent hematological diseases were lymphoma (30%), multiple myeloma (30%), and chronic lymphocytic leukemia (15%). On the WHO severity scale, 12.8% of the cancer patients were classified as mild, 41% as moderate, and 46.2% as severe. Most of the hematological patients were treated with hydroxychloroquine (89%) and lopinavir/ritonavir (79.5%); 51% of the patients received corticoids and 30.8% (n=12) received tocilizumab. In the multivariate analysis, we observed that only age >70 years and C reactive protein >10 mg/dl were associated with higher risk of death (odds ratio 34.86 (3.407-356.8) and 13.56 (1.28-143.45), respectively). An unfavorable impact of chemotherapy administration on COVID-19 outcome was not demonstrated. The non-hematological and hematological patients had similar clinical and laboratory characteristics; however, but mortality was higher in hematological patients (35.9% vs. 13.2%; Odds Ratio 6.5; 95% CI=1.868-23.688; P=0.003). Conclusion: Patients with hematological malignancies had a similar incidence of COVID-19, but the severity and mortality were much higher than in non-cancer patients even in the absence of therapy. Funding Statement: This work received funding from the research contract COV20/00181 from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III. Our research group was supported by the Fundacion Cris contra el cancer. Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: This retrospective study was approved by the Hospital Universitario 12 de Octubre Institutional Review Board (n 20/182). |
| اللغة: | English |
| تدمد: | 1600-0609 0902-4441 |
| DOI: | 10.1111/ejh.13493 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b46de7b73fc24b31b2a3d3979f702bf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2b46de7b73fc24b31b2a3d3979f702bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000609 09024441 |
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| DOI: | 10.1111/ejh.13493 |