Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer's Disease
| العنوان: | Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer's Disease |
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| المؤلفون: | Wiesje M. van der Flier, Judith Manniën, Afina W. Lemstra, Marcel G. M. Olde Rikkert, Marleen van de Beek, Janne M. Papma, Inez H.G.B. Ramakers, Inger van Steenoven, Pauline Aalten, Frank Jan de Jong, Huiberdina L. Koek |
| المساهمون: | Neurology, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Amsterdam Neuroscience - Neurodegeneration, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science |
| المصدر: | American Journal of Alzheimer's Disease and Other Dementias, 70, 2, pp. 389-397 Journal of Alzheimers Disease, 70(2), 387-395. IOS Press BV Journal of Alzheimer's Disease, 70(2), 387-395. IOS Press van de Beek, M, van Steenoven, I, Ramakers, I H G B, Aalten, P, Koek, H L, Olde Rikkert, M G M, Manniën, J, Papma, J M, de Jong, F J, Lemstra, A W & van der Flier, W M 2019, ' Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 70, no. 2, pp. 387-395 . https://doi.org/10.3233/JAD-190041 Journal of Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, 70, 389-397 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1], SYMPTOMS, STRESS, Cohort Studies, 0302 clinical medicine, Quality of life, Longitudinal Studies, PREDICTORS, General Neuroscience, General Medicine, Middle Aged, Alzheimer's disease, CAREGIVER BURDEN, Cognitive test, PREVALENCE, Psychiatry and Mental health, Clinical Psychology, Cohort, dementia with Lewy Bodies, Female, Geriatric Depression Scale, NURSING-HOME ADMISSION, Alzheimer’s disease, Research Article, Lewy Body Disease, medicine.medical_specialty, Visual analogue scale, Context (language use), DIAGNOSIS, 03 medical and health sciences, Alzheimer Disease, PEOPLE, Internal medicine, mental disorders, medicine, MANAGEMENT, Humans, Dementia, Aged, Psychiatric Status Rating Scales, quality of Life, business.industry, Dementia with Lewy bodies, medicine.disease, 030104 developmental biology, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Follow-Up Studies, dementia |
| الوصف: | Contains fulltext : 208145.pdf (Publisher’s version ) (Open Access) BACKGROUND: Quality of Life (QoL) is an important outcome measure in dementia, particularly in the context of interventions. Research investigating longitudinal QoL in dementia with Lewy bodies (DLB) is currently lacking. OBJECTIVE: To investigate determinants and trajectories of QoL in DLB compared to Alzheimer's disease (AD) and controls. METHODS: QoL was assessed annually in 138 individuals, using the EQ5D-utility-score (0-100) and the health-related Visual Analogue Scale (VAS, 0-100). Twenty-nine DLB patients (age 69+/-6), 68 AD patients (age 70+/-6), and 41 controls (age 70+/-5) were selected from the Dutch Parelsnoer Institute-Neurodegenerative diseases and Amsterdam Dementia Cohort. We examined clinical work-up over time as determinants of QoL, including cognitive tests, neuropsychiatric inventory, Geriatric Depression Scale (GDS), and disability assessment of dementia (DAD). RESULTS: Mixed models showed lower baseline VAS-scores in DLB compared to AD and controls (AD: beta+/-SE = -7.6+/-2.8, controls: beta+/-SE = -7.9+/-3.0, p < 0.05). An interaction between diagnosis and time since diagnosis indicated steeper decline on VAS-scores for AD patients compared to DLB patients (beta+/-SE = 2.9+/-1.5, p < 0.1). EQ5D-utility-scores over time did not differ between groups. Higher GDS and lower DAD-scores were independently associated with lower QoL in dementia patients (GDS: VAS beta+/-SE = -1.8+/-0.3, EQ5D-utility beta+/-SE = -3.7+/-0.4; DAD: VAS = 0.1+/-0.0, EQ5D-utility beta+/-SE = 0.1+/-0.1, p < 0.05). No associations between cognitive tests and QoL remained in the multivariate model. CONCLUSION: QoL is lower in DLB, while in AD QoL shows steeper decline as the disease advances. Our results indicate that non-cognitive symptoms, more than cognitive symptoms, are highly relevant as they impact QoL. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1387-2877 1533-3175 |
| DOI: | 10.3233/jad-190041 |
| DOI: | 10.3233/JAD-190041 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3f09e96a59a3722145902a2ce7b170 https://doi.org/10.3233/jad-190041 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2b3f09e96a59a3722145902a2ce7b170 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13872877 15333175 |
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| DOI: | 10.3233/jad-190041 |