The human renal lymphatics under normal and pathological conditions
| العنوان: | The human renal lymphatics under normal and pathological conditions |
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| المؤلفون: | Shigehiro Soh, Hideko Kiguchi, Yukio Ishikawa, Hiroshi Morita, Masayo Kimura-Matsumoto, Toshiharu Ishii, Shigeki Ishiguro, T Hasegawa, Shinji Sato, Yoshikiyo Akasaka, Yuri Akishima-Fukasawa, Kinji Ito |
| المصدر: | Histopathology |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, renal cell carcinoma, Pathology, medicine.medical_specialty, Histology, Lymphovascular invasion, medicine.medical_treatment, Renal cortex, Biology, Kidney, urologic and male genital diseases, Pathology and Forensic Medicine, Antibodies, Monoclonal, Murine-Derived, D2-40, Renal cell carcinoma, medicine, Humans, Carcinoma, Renal Cell, Aged, Lymphatic Vessels, Antibodies, Monoclonal, Kidney metabolism, Original Articles, General Medicine, Anatomy, Middle Aged, medicine.disease, Immunohistochemistry, Kidney Neoplasms, Nephrectomy, renal anatomy, medicine.anatomical_structure, Lymphatic system, renal lymphatics, Female, Kidney Diseases, Kidney disease |
| الوصف: | Ishikawa Y, Akasaka Y, Kiguchi H, Akishima-Fukasawa Y, Hasegawa T, Ito K, Kimura-Matsumoto M, Ishiguro S, Morita H, Sato S, Soh S & Ishii T (2006) Histopathology 49, 265–273 The human renal lymphatics under normal and pathological conditions Aims The renal lymphatics have not been fully documented in humans. The aim of this study was to clarify the morphology of the human renal lymphatic system under normal and pathological conditions by immunohistochemistry using anti-D2-40 antibody. Methods and results Normal and pathological renal tissues obtained at autopsy as well as nephrectomy specimens with renal cell carcinoma (RCC) were used. Thin sections were immunostained with antibodies against D2-40 and CD31. In normal kidney, D2-40+ lymphatics were abundant in the interstitium around the interlobar and arcuate arteries/veins but sporadic in those around the glomeruli or between the tubules in the cortex. A few lymphatics contained erythrocytes in their lumina. Lymphatics were seldom present in the medulla. In RCC cases, lymphatics were evident at the tumour margin, whereas CD31+ capillaries were abundant throughout the tumour and lymphatics were increased in the fibrous interstitium around the tumour. Lymphatic invasion by RCC cells was also detectable. D2-40+ lymphatics were evident in other pathological conditions and end-stage kidney had a denser lymphatic distribution than normal kidney. Conclusions Lymphatics are abundant around the arteries/veins and are also present in the renal cortex and medulla. D2-40 immunostaining is helpful for investigating the pathophysiological role of renal lymphatics. |
| تدمد: | 1365-2559 0309-0167 |
| DOI: | 10.1111/j.1365-2559.2006.02478.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0faf819a6cb369d91c81601157da82 https://doi.org/10.1111/j.1365-2559.2006.02478.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2b0faf819a6cb369d91c81601157da82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652559 03090167 |
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| DOI: | 10.1111/j.1365-2559.2006.02478.x |