Bio-based glyco-bolaamphiphile forms a temperature-responsive hydrogel with tunable elastic properties
| العنوان: | Bio-based glyco-bolaamphiphile forms a temperature-responsive hydrogel with tunable elastic properties |
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| المؤلفون: | Sophie Roelants, Wim Soetaert, Viviana Cristiglio, Niki Baccile, Guylaine Ducouret, Martha Brennich, Patrick Le Griel, Lisa Van Renterghem |
| المساهمون: | Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (LCMCP-SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University [Belgium] (UGENT), Sciences et Ingénierie de la Matière Molle (UMR 7615) (SIMM), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Institut Laue-Langevin (ILL), ILL |
| المصدر: | Soft Matter Soft Matter, Royal Society of Chemistry, 2018, 14 (38), pp.7859-7872. ⟨10.1039/C8SM01167B⟩ |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Phase transition, Sophorose, Strain (chemistry), Chemistry, Transition temperature, Bolaamphiphile, Substrate (chemistry), 02 engineering and technology, General Chemistry, Activation energy, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Chemical engineering, 0210 nano-technology, Elastic modulus, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft] |
| الوصف: | International audience; A bio-based glycolipid bolaamphiphile (glyco-bolaamphiphile) has recently been produced (Van Renterghem et al., Biotechnol. Bioeng., 2018, 115, 1195–1206) on a gram scale by using the genetically-engineered S. bombicola strain Δat Δsble Δfao1. The glyco-bolaamphiphile bears two symmetrical sophorose headgroups at the extremities of a C16:0 (ω-1 hydroxylated palmitic alcohol) spacer. Its atypical structure has been obtained by redesigning the S. bombicola strain Δat Δsble, producing non-symmetrical glyco-bolaamphiphile, with an additional knock out (Δfao1) and feeding this new strain with fatty alcohols. The molecular structure of the glyco-bolaamphiphile is obtained by feeding the new strain a saturated C16 substrate (palmitic alcohol), which enables the biosynthesis of bolaform glycolipids. In this work, we show that the bio-based glyco-bolaamphiphile readily forms a hydrogel in water at room temperature, and that the hydrogel formation depends on the formation of self-assembled fibers. Above 28 °C, the molecules undergo a gel-to-sol transition, which is due to a fiber-to-micelle phase change. We provide a quantitative description of the Self-Assembled Fibrillar Network (SAFiN) hydrogel formed by the glyco-bolaampiphile. We identify the sol–gel transition temperature, the gelling time, and the minimal gel concentration; additionally, we explore the fibrillation mechanism as a function of time and temperature and determine the activation energy of the micelle-to-fiber phase transition. These parameters allow control of the elastic properties of the glyco-bolaamphiphile hydrogel: at 3 wt% and 25 °C, the elastic modulus G′ is above the kPa range, while at 5 °C, G′ can be tuned between 100 Pa and 20 kPa, by controlling the undercooling protocol. |
| تدمد: | 1744-683X 1744-6848 |
| DOI: | 10.1039/C8SM01167B |
| DOI: | 10.1039/C8SM01167B⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad0ebb5bb41e16c8b7c6c486bd98c31 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2ad0ebb5bb41e16c8b7c6c486bd98c31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1744683X 17446848 |
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| DOI: | 10.1039/C8SM01167B |