Infantile haemangioma expresses embryonic stem cell markers
| العنوان: | Infantile haemangioma expresses embryonic stem cell markers |
|---|---|
| المؤلفون: | Ryan W.J. Steel, Swee T. Tan, Jun Jia, Darren J. Day, Helen D. Brasch, Anasuya Vishvanath, Heather A Best, Tinte Itinteang |
| المصدر: | Journal of Clinical Pathology. 65:394-398 |
| بيانات النشر: | BMJ, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | STAT3 Transcription Factor, Stage-Specific Embryonic Antigens, Pathology, medicine.medical_specialty, Skin Neoplasms, Gene Expression, Mice, Nude, Mice, SCID, Biology, Pathology and Forensic Medicine, Mice, Mice, Inbred NOD, In vivo, Gene expression, Biomarkers, Tumor, medicine, Animals, Humans, Child, Embryonic Stem Cells, Cell Proliferation, Reverse Transcriptase Polymerase Chain Reaction, Cell growth, Mesenchymal stem cell, Teratoma, Infant, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Phenotype, Embryonic stem cell, embryonic structures, Immunohistochemistry, Hemangioma, Octamer Transcription Factor-3, Neoplasm Transplantation |
| الوصف: | The origin of infantile haemangioma (IH) remains enigmatic. A primitive mesodermal phenotype origin of IH with the ability to differentiate down erythropoietic and terminal mesenchymal lineages has recently been demonstrated.To investigate the expression of human embryonic stem cell (hESC) markers in IH and to determine whether IH-derived cells have the functional capacity to form teratoma in vivo.Immunohistochemical staining and quantitative reverse transcription PCR were used to investigate the expression of hESC markers in IH biopsies. The ability of cells derived from proliferating IH to form teratomas in a mouse xenograft model was investigated.The hESC markers, Oct-4, STAT-3 and stage-specific embryonic antigen 4 were collectively expressed on the endothelium of proliferating IH lesions, whereas Nanog was not. Nanog was expressed by cells in the interstitium and these cells did not express Oct-4, stage-specific embryonic antigen 4 or STAT-3. Proliferating IH-derived cells were unable to form teratomas in severely compromised immunodeficient/non-obese diabetic mice.The novel expression of hESC on two different populations of cells in proliferating IH and their inability to form teratomas in vivo infer the presence of a primitive cellular origin for IH downstream from hESC. |
| تدمد: | 1472-4146 0021-9746 |
| DOI: | 10.1136/jclinpath-2011-200462 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa9cf2019002c1e055917da4f388b24 https://doi.org/10.1136/jclinpath-2011-200462 |
| رقم الانضمام: | edsair.doi.dedup.....2aa9cf2019002c1e055917da4f388b24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
|---|---|
| DOI: | 10.1136/jclinpath-2011-200462 |