Longitudinal study of CSF biomarkers in patients with Alzheimer's disease
| العنوان: | Longitudinal study of CSF biomarkers in patients with Alzheimer's disease |
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| المؤلفون: | Kaj Blennow, Oskar Hansson, Peder Buchhave, Erik Stomrud, Henrik Zetterberg, Lennart Minthon, Elisabet Londos, Niels Andreasen |
| المصدر: | PLoS ONE, Vol 4, Iss 7, p e6294 (2009) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Oncology, Male, medicine.medical_specialty, Longitudinal study, Pathology, Neurology, lcsh:Medicine, tau Proteins, Cohort Studies, Cerebrospinal fluid, Alzheimer Disease, Internal medicine, mental disorders, medicine, Humans, Effects of sleep deprivation on cognitive performance, Longitudinal Studies, lcsh:Science, Aged, Aged, 80 and over, Neuroscience/Cognitive Neuroscience, Multidisciplinary, Amyloid beta-Peptides, business.industry, lcsh:R, Case-control study, Middle Aged, medicine.disease, Case-Control Studies, Neurological Disorders/Cognitive Neurology and Dementia, Cohort, Female, lcsh:Q, Alzheimer's disease, business, Neurological Disorders/Alzheimer Disease, Biomarkers, Cohort study, Research Article |
| الوصف: | BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p50% (p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4625249ad6b7090dcc2034844bf184 http://europepmc.org/articles/PMC2707615?pdf=render |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a4625249ad6b7090dcc2034844bf184 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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