Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting
| العنوان: | Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting |
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| المؤلفون: | Laurent Leclercq, Ian Soulairol, Tahmer Sharkawi, Noelia M. Sanchez-Ballester, Bernard Bataille, Rihab Benabbas |
| المساهمون: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | AAPS PharmSciTech AAPS PharmSciTech, American Association of Pharmaceutical Scientists, 2020, 21 (3), pp.2373-2378. ⟨10.1208/s12249-020-1633-3⟩ |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Thermogravimetric analysis, Materials science, Carboxylic acid, Size-exclusion chromatography, Multiangle light scattering, Drug Evaluation, Preclinical, Pharmaceutical Science, 02 engineering and technology, Aquatic Science, 030226 pharmacology & pharmacy, Excipients, 03 medical and health sciences, Tableting, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, X-Ray Diffraction, physicochemical characterization, Hardness, Drug Discovery, Spectroscopy, Fourier Transform Infrared, Filler Excipient, medicine, Ecology, Evolution, Behavior and Systematics, swelling force, Alginic acid, Mechanical Phenomena, chemistry.chemical_classification, direct compression, disintegration, Ecology, Alginic Acid, General Medicine, 021001 nanoscience & nanotechnology, Elasticity, [CHIM.POLY]Chemical Sciences/Polymers, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, chemistry, Chemical engineering, Swelling, medicine.symptom, 0210 nano-technology, Agronomy and Crop Science, Tablets |
| الوصف: | International audience; The aim of this study is to investigate the relationship between the structural, molecular, and particulate properties of alginic acid and its functional characteristics in direct compression (tabletability, compressibility, elasticity, deformation mechanism, and disintegration ability). Therefore, accurate characterization of two different batches of alginic acid was executed (X-ray powder diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electronic microscopy, 1H nuclear magnetic resonance, size exclusion chromatographymulti angle light scattering, viscosimetry, carboxylic acid titration, powder flowability, true density, laser granulometry). Results showed that molecular weight seems to affect tablet properties and that the alginic acid with the lowest molecular weight provides the hardest tablets with the lowest elastic recovery. Furthermore, these results show the potential interest of exploiting alginic acid as filler excipient in tablet formulation. Finally, disintegration properties of tested materials were found to be close to that of commercial superdisintegrants (Glycolys® and Kollidon Cl®) but not correlated to their swelling force. It can be concluded, for the first time, that the determination of alginic acid molecular weight seems key for applications in direct compression and in particular for obtaining tablets with reproducible strength. |
| تدمد: | 1530-9932 |
| DOI: | 10.1208/s12249-020-1633-3⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a38e3d138e0b202b346edd14ac579d5 https://pubmed.ncbi.nlm.nih.gov/32096096 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a38e3d138e0b202b346edd14ac579d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15309932 |
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| DOI: | 10.1208/s12249-020-1633-3⟩ |