Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry
| العنوان: | Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry |
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| المؤلفون: | Noortje IJssennagger, Saskia W.C. van Mil, Arie K. Kies, M.S. Gilbert |
| المساهمون: | Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism |
| المصدر: | American journal of physiology. Gastrointestinal and liver physiology, 315(2), G159-G170. American Physiological Society American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(2), G159-G170 American Journal of Physiology-Gastrointestinal and Liver Physiology 315 (2018) 2 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Animal Nutrition, Swine, Physiology, Metabolite, Biology, Inflammatory bowel disease, Microbiology, Nitric oxide, Birds, Epithelial Damage, 03 medical and health sciences, chemistry.chemical_compound, Metabolomics, Protein fermentation, Physiology (medical), Dietary Carbohydrates, medicine, Animals, Humans, Intestinal disease, Pig, Hepatology, Broiler, Gastroenterology, Hindgut, medicine.disease, Diervoeding, Gastrointestinal Tract, Intestinal Diseases, Diarrhea, 030104 developmental biology, chemistry, Fermentation, WIAS, Dietary Proteins, Gut health, medicine.symptom, Human |
| الوصف: | The amount of dietary protein is associated with intestinal disease in different vertebrate species. In humans, this is exemplified by the association between high-protein intake and fermentation metabolite concentrations in patients with inflammatory bowel disease. In production animals, dietary protein intake is associated with postweaning diarrhea in piglets and with the occurrence of wet litter in poultry. The underlying mechanisms by which dietary protein contributes to intestinal problems remain largely unknown. Fermentation of undigested protein in the hindgut results in formation of fermentation products including short-chain fatty acids, branched-chain fatty acids, ammonia, phenolic and indolic compounds, biogenic amines, hydrogen sulfide, and nitric oxide. Here, we review the mechanisms by which these metabolites may cause intestinal disease. Studies addressing how different metabolites induce epithelial damage rely mainly on cell culture studies and occasionally on mice or rat models. Often, contrasting results were reported. The direct relevance of such studies for human, pig, and poultry gut health is therefore questionable and does not suffice for the development of interventions to improve gut health. We discuss a roadmap to improve our understanding of gut metabolites and microbial species associated with intestinal health in humans and production animals and to determine whether these metabolite/bacterial networks cause epithelial damage. The outcomes of these studies will dictate proof-of-principle studies to eliminate specific metabolites and or bacterial strains and will provide the basis for interventions aiming to improve gut health. |
| وصف الملف: | application/octet-stream; application/pdf |
| اللغة: | English |
| تدمد: | 0193-1857 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ec70a59d5e5e666178a7697bf60b99 https://pure.amc.nl/en/publications/protein-fermentation-in-the-gut-implications-for-intestinal-dysfunction-in-humans-pigs-and-poultry(8eb8cde2-2ab8-42b7-b966-2e549160dd36).html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....29ec70a59d5e5e666178a7697bf60b99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01931857 |
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