Therapy-Related Chronic Myeloid Leukemia: An Epidemiological, Clinical and Pathogenetic Appraisal
| العنوان: | Therapy-Related Chronic Myeloid Leukemia: An Epidemiological, Clinical and Pathogenetic Appraisal |
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| المؤلفون: | Ricardo C. T. Aguiar |
| المصدر: | Leukemia & Lymphoma. 29:17-26 |
| بيانات النشر: | Informa UK Limited, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Population, Antineoplastic Agents, Context (language use), Myelogenous, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, Epidemiology, medicine, Humans, education, neoplasms, Leukemia, Radiation-Induced, Chemotherapy, education.field_of_study, Radiotherapy, business.industry, Incidence, Myeloid leukemia, Neoplasms, Second Primary, Hematology, medicine.disease, Radiation therapy, Leukemia, Immunology, business |
| الوصف: | Second primary cancers represent an important complication of modern chemotherapy and radiotherapy. Therapy-related (tr) leukemias are among the most common second malignancies in both pediatric and adult populations. Whereas a reasonable amount of data is available regarding the epidemiology, molecular pathogenesis, clinical behavior and response to therapy of second primary acute leukemias, very little is known about therapy-related chronic myeloid leukemia (tr-CML). A better characterization of this entity could increase our understanding about the mechanisms of carcinogenesis, specially the induction of specific genetic abnormalities, e.g., BCR-ABL fusion, following chemotherapy and/or radiotherapy exposure, could facilitate the investigation of the kinetics of the development of CML, and also provide a model to study molecular events that might precede its development. Review of 32 tr-CML cases suggests that there are no clinically appreciable differences between tr-CML and de novo CML cases. Analysis of large epidemiological studies that investigated the risk of second primary leukemias has not shown any clear evidence of a higher risk of CML among individuals who underwent treatment for a primary cancer over the general population. The cancer-predisposing syndromes, the detection of BCR-ABL transcripts in healthy individuals, and the induction in vitro of BCR-ABL fusions by ionizing radiation, are all discussed in the context of tr-CML. Finally, the need for a large epidemiological study to specifically assess the risk of developing second primary CML after chemotherapy and/or radiotherapy is stressed. |
| تدمد: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199809058378 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dd8cac165cfbf2afda62e7314f9e14 https://doi.org/10.3109/10428199809058378 |
| رقم الانضمام: | edsair.doi.dedup.....29dd8cac165cfbf2afda62e7314f9e14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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| DOI: | 10.3109/10428199809058378 |