Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides
| العنوان: | Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides |
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| المؤلفون: | Jose Oñate-Garzón, Jean Paul Delgado, Yamil Liscano |
| المصدر: | Molecules Molecules, Vol 25, Iss 4245, p 4245 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Computer science, Cell Survival, In silico, High selectivity, Pharmaceutical Science, Peptide, Tumor cells, Antineoplastic Agents, Computational biology, Review, anticancer, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, 0302 clinical medicine, lcsh:Organic chemistry, Anti-Infective Agents, Cell Line, Tumor, Drug Discovery, Humans, Physical and Theoretical Chemistry, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Organic Chemistry, Rational design, Computational Biology, DUAL (cognitive architecture), Antimicrobial, peptide, chemistry, in silico, Chemistry (miscellaneous), Reduced toxicity, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, Antimicrobial Cationic Peptides |
| الوصف: | Peptides are naturally produced by all organisms and exhibit a wide range of physiological, immunomodulatory, and wound healing functions. Furthermore, they can provide with protection against microorganisms and tumor cells. Their multifaceted performance, high selectivity, and reduced toxicity have positioned them as effective therapeutic agents, representing a positive economic impact for pharmaceutical companies. Currently, efforts have been made to invest in the development of new peptides with antimicrobial and anticancer properties, but the poor stability of these molecules in physiological environments has triggered a bottleneck. Therefore, some tools, such as nanotechnology and in silico approaches can be applied as alternatives to try to overcome these obstacles. In silico studies provide a priori knowledge that can lead to the development of new anticancer peptides with enhanced biological activity and improved stability. This review focuses on the current status of research in peptides with dual antimicrobial–anticancer activity, including advances in computational biology using in silico analyses as a powerful tool for the study and rational design of these types of peptides. |
| اللغة: | English |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cd8e7d39a17b1c92b6d6d3a126ce24 http://europepmc.org/articles/PMC7570524 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....29cd8e7d39a17b1c92b6d6d3a126ce24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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