Predisposing Factors Responsible for the Occurrence of Bacterial Purulent Meningoencephalitis
| العنوان: | Predisposing Factors Responsible for the Occurrence of Bacterial Purulent Meningoencephalitis |
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| المؤلفون: | Danko Živković, Branko Jakovljevic, Dragica Terzic, Olgica Gajovic, Brankica Dupanovic, Bogdanka Andric, Zoran Todorovic |
| المصدر: | Acta Clinica Croatica, Vol 56., Iss 1., Pp 117-123 (2017) |
| بيانات النشر: | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pathology, lcsh:Medicine, Antineoplastic Agents, Disease, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, Risk Factors, Meningoencephalitis, Internal medicine, Diabetes mellitus, Craniocerebral Trauma, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Young adult, Treatment outcome, Prospective cohort study, Survival rate, Meningitis, bacterial, Aged, Retrospective Studies, business.industry, lcsh:R, Age Factors, Retrospective cohort study, General Medicine, Middle Aged, Prognosis, medicine.disease, 3. Good health, Montenegro, Survival Rate, Causality, Logistic Models, Cardiovascular Diseases, Multivariate Analysis, Etiology, Female, Nervous System Diseases, business, 030217 neurology & neurosurgery |
| الوصف: | Bacterial purulent meningoencephalitis (BPME) is a life-threatening infectious disease caused by various pyogenic bacteria. The disease is defined as the inflammatory process of leptomeninges (visceral layer, pia mater and arachnoid membrane) and brain parenchyma with exudates in the subarachnoid space and surrounding brain structures. The aim of the study was to define the predisposing factors responsible for the occurrence of BPME, as well as the possible correlation between the presence of predisposing factors and patient demographic characteristics, etiology and outcome of the disease. This retrospective-prospective study included 90 patients with BPME confirmed by clinical, neuroradiological and laboratory findings. Multivariate logistic regression models were fitted to analyze the impact of the predisposing factors on the disease outcomes. Predisposing factors that were related to BPME were found in 61% of patients. Cranial trauma as the leading factor was recorded in 23.3% of patients, followed by previous neurological disease in 14.4% of patients, while 13 patients were exposed to previous chemotherapy or long-term corticosteroid therapy. Cardiovascular diseases were reported in 12.2% and diabetes in 7.8% of patients. The existence of cardiovascular diseases significantly influenced unfavorable outcome of the disease, i.e. ”deceased” in comparison to ”cured” (OR=8.418; 95% CI=1.007-76.270), independently of age and gender. None of the examined predisposing factors was significantly related to the ”recovered with sequels” outcome as compared with ”cured” outcome. Older age and presence of cardiovascular disease as a predisposing factor significantly increased the odds of the BPME unfavorable outcome ”deceased” as compared to ”cured” outcome. |
| اللغة: | English |
| تدمد: | 1333-9451 0353-9466 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b1a65305a4fd8a7ae218698d2b03f8 http://hrcak.srce.hr/file/271956 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....29b1a65305a4fd8a7ae218698d2b03f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13339451 03539466 |
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