Venous thromboembolism in association with features of the metabolic syndrome
| العنوان: | Venous thromboembolism in association with features of the metabolic syndrome |
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| المؤلفون: | George Fodor, Jacques Genest, Qilong Yi, Matthew J. McQueen, Joel G. Ray, A Rathe, Patrick Sheridan, Malcolm Arnold, Jeffrey L. Probstfield, Mary Micks, Hope Investigators, Claes Held, Salim Yusuf, J Pogue, Eva Lonn, Clive Kearon |
| المصدر: | QJM. 100:679-684 |
| بيانات النشر: | Oxford University Press (OUP), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Blood Pressure, Body Mass Index, Cohort Studies, Risk Factors, Diabetes mellitus, Internal medicine, Odds Ratio, medicine, Humans, Obesity, cardiovascular diseases, Risk factor, Prospective cohort study, Triglycerides, Aged, Metabolic Syndrome, Waist-Hip Ratio, business.industry, Incidence, Hazard ratio, Venous Thromboembolism, General Medicine, Odds ratio, Middle Aged, medicine.disease, Surgery, Venous thrombosis, Female, Metabolic syndrome, business, Cohort study |
| الوصف: | Background: Central obesity, diabetes mellitus, dyslipidaemia and chronic hypertension-features of the metabolic syndrome-have been individually associated with venous thromboembolism (VTE). However, whether each of these factors additively increases the risk of VTE is uncertain. Aim: To determine whether features of the metabolic syndrome independently increase the risk of VTE. Design: Prospective cohort study derived from the Heart Outcomes Prevention Evaluation 2 (HOPE-2) randomized clinical trial. Setting: One hundred and forty-five clinical centres in 13 countries. Methods: We studied 5522 adults aged >55 years with cardiovascular disease or diabetes mellitus. At enrolment, 35% had 0-1 features of the metabolic syndrome, 30% had two, 24% had three and 11% had four. We defined symptomatic VTE as an objectively confirmed new episode of deep-vein thrombosis or pulmonary embolism. Results: VTE occurred in 88 individuals during a median 5.0 years of follow-up. The incidence rate of VTE (per 100 person-years) was 0.30 with 0-1 features, 0.36 with two features, 0.38 with three features and 0.40 with four features of the metabolic syndrome (trend p=0.43). Relative to the presence of 0-1 features of the metabolic syndrome, the adjusted hazard ratio (95%Cl) for VTE was 1.22 (0.71-2.08) with two features, 1.25 (0.70-2.24) with three features, and 1.26 (0.59-2.69) with four features. Discussion: The number of features of the metabolic syndrome present was not a clinically important risk factor for VTE in older adults with vascular arterial disease. |
| تدمد: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcm083 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293858250248a74de694ac4049a7a201 https://doi.org/10.1093/qjmed/hcm083 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....293858250248a74de694ac4049a7a201 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602393 14602725 |
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| DOI: | 10.1093/qjmed/hcm083 |